| Gene Symbol |
Rnf169
|
| Entrez Gene |
108937
|
| Alt Symbol |
2900057K09Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 169
|
| Other Description |
E3 ubiquitin-protein ligase RNF169
|
| Swissprots |
Q69Z47 E9Q7F2
|
| Accessions |
E9Q7F2 AK076142 BAC36213 AK081673 AK085104 AK173319 BAD32597 BC062943 XM_006507185 XP_006507248 XM_006507187 XP_006507250 XM_006507188 XP_006507251 NM_175388 NP_780597
|
| Function |
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000250}. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products (By similarity). {ECO:0000250}.
|