Gene Symbol | Rnf169 |
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Entrez Gene | 108937 |
Alt Symbol | 2900057K09Rik |
Species | Mouse |
Gene Type | protein-coding |
Description | ring finger protein 169 |
Other Description | E3 ubiquitin-protein ligase RNF169 |
Swissprots | Q69Z47 E9Q7F2 |
Accessions | E9Q7F2 AK076142 BAC36213 AK081673 AK085104 AK173319 BAD32597 BC062943 XM_006507185 XP_006507248 XM_006507187 XP_006507250 XM_006507188 XP_006507251 NM_175388 NP_780597 |
Function | Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus, nucleoplasm {ECO:0000250}. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products (By similarity). {ECO:0000250}. |
RNF169 CRISPR/Cas9 KO Plasmid (m) - sc-430878 from Santa Cruz Biotechnology
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RNF169 HDR Plasmid (m) - sc-430878-HDR from Santa Cruz Biotechnology
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RNF169 Double Nickase Plasmid (m) - sc-430878-NIC from Santa Cruz Biotechnology
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RNF169 Double Nickase Plasmid (m2) - sc-430878-NIC-2 from Santa Cruz Biotechnology
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RNF169 CRISPR Activation Plasmid (m) - sc-430878-ACT from Santa Cruz Biotechnology
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RNF169 CRISPR Activation Plasmid (m2) - sc-430878-ACT-2 from Santa Cruz Biotechnology
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RNF169 Lentiviral Activation Particles (m) - sc-430878-LAC from Santa Cruz Biotechnology
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RNF169 Lentiviral Activation Particles (m2) - sc-430878-LAC-2 from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU172511 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN40335 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40335 from Sigma-Aldrich
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RNF169 siRNA (Mouse) - CRN0976 from Cohesion Biosciences
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RNF169 - MBS8233460 from MyBioSource
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shRNA set against Mouse RNF169 (NM_175388.3) - SHH396944 from Creative biogene
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RNF169 shRNA Plasmid (Mouse) - CHN0976 from Cohesion Biosciences
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