| Gene Symbol |
Igf2r
|
| Entrez Gene |
16004
|
| Alt Symbol |
AI661837, CD222, CI-MPR, M6P/IGF2R, Mpr300
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
insulin-like growth factor 2 receptor
|
| Other Description |
300 kDa mannose 6-phosphate receptor|CI Man-6-P receptor|IGF-II receptor|IGF-II/CI-MPR|M6P/IGF2 receptor|M6PR|MPR 300|cation-independent MPR|cation-independent mannose 6-phosphate receptor|cation-independent mannose-6-phosphate receptor|insulin-like growth factor II receptor|mannose-6-phosphate receptor, cation independent
|
| Swissprots |
Q61822 Q07113 Q6LED1
|
| Accessions |
AAA37921 AAA37922 AAA39320 AAA39483 AAA98844 AAM22159 EDL02049 EDL02050 EDL02051 Q07113 AK053045 BAC35249 AK088699 BAC40512 AY644391 AAT46419 BB865604 BC031190 AAH31190 BC043457 AAH43457 BC055018 AAH55018 BC115601 BC150817 AAI50818 BC171973 AAI71973 BP757292 BQ900123 CA324933 CD545656 CF167933 CK639250 CN461279 CN530622 FJ425888 FJ425889 L19500 AAA16037 U04710 AAA19568 X60389 CAA42940 NM_010515 NP_034645
|
| Function |
Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. {ECO:0000250}.
|
| Subcellular Location |
Lysosome membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Lysosome
|
