ENO2
| Gene Symbol | ENO2 |
|---|---|
| Entrez Gene | 2026 |
| Alt Symbol | HEL-S-279, NSE |
| Species | Human |
| Gene Type | protein-coding |
| Description | enolase 2 (gamma, neuronal) |
| Other Description | 2-phospho-D-glycerate hydro-lyase|2-phospho-D-glycerate hydrolyase|epididymis secretory protein Li 279|gamma-enolase|neural enolase|neuron specific gamma enolase|neuron-specific enolase|neurone-specific enolase |
| Swissprots | P09104 Q96J33 B7Z2X9 |
| Accessions | AAB51320 CAA36215 CBN61368 EAW88709 EAW88710 EAW88711 P09104 AK124656 BAG54062 AK290525 BAF83214 AK295220 BAH12015 AK312402 BAG35316 BC002745 AAH02745 BT007383 AAP36047 CR536582 CAG38819 DQ893819 ABM84745 EU176168 ABW03619 EU794607 ACJ13661 M22349 AAB59554 M36768 AAA52388 X13120 CAA31512 X14327 CAA32505 Y00691 NM_001975 NP_001966 |
| Function | Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. {ECO:0000250}. |
| Tissue Specificity | The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. |
| Top Pathways | Glycolysis / Gluconeogenesis, RNA degradation, Biosynthesis of amino acids, Carbon metabolism |
γ Enolase CRISPR/Cas9 KO Plasmid (h) - sc-400763 from Santa Cruz Biotechnology
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γ Enolase HDR Plasmid (h) - sc-400763-HDR from Santa Cruz Biotechnology
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γ Enolase Double Nickase Plasmid (h) - sc-400763-NIC from Santa Cruz Biotechnology
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γ Enolase Double Nickase Plasmid (h2) - sc-400763-NIC-2 from Santa Cruz Biotechnology
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γ Enolase CRISPR Activation Plasmid (h) - sc-400763-ACT from Santa Cruz Biotechnology
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γ Enolase CRISPR Activation Plasmid (h2) - sc-400763-ACT-2 from Santa Cruz Biotechnology
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γ Enolase Lentiviral Activation Particles (h) - sc-400763-LAC from Santa Cruz Biotechnology
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γ Enolase Lentiviral Activation Particles (h2) - sc-400763-LAC-2 from Santa Cruz Biotechnology
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γ Enolase siRNA (h) - sc-37045 from Santa Cruz Biotechnology
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γ Enolase shRNA Plasmid (h) - sc-37045-SH from Santa Cruz Biotechnology
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γ Enolase shRNA (h) Lentiviral Particles - sc-37045-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN7873 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7873 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06838 from Sigma-Aldrich
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ENO2 siRNA (Human) - CRH1405 from Cohesion Biosciences
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Enolase 2/Neuron-specific Enolase RNAi - H00002026-R01 from Novus Biologicals
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ENO2 - MBS8232821 from MyBioSource
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shRNA set against Human ENO2 (NM_001975.2) - SHH285825 from Creative biogene
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shRNA set against Human ENO2(NM_001975.2) - SHH033725 from Creative biogene
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Human ENO2 siRNA - orb261907 from Biorbyt
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ENO2 shRNA Plasmid (Human) - CHH1405 from Cohesion Biosciences
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ENO2 miRNA 3'UTR clone - MiUTR1H-03226 from Creative biogene
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