TYK2

Gene Symbol TYK2
Entrez Gene 7297
Alt Symbol IMD35, JTK1
Species Human
Gene Type protein-coding
Description tyrosine kinase 2
Other Description non-receptor tyrosine-protein kinase TYK2
Swissprots Q6QB10 Q96CH0 P29597
Accessions AAS37680 EAW84099 EAW84100 P29597 AK222672 BAD96392 AK303627 BAG64635 AK308360 AK308379 BC014243 AAH14243 CR995139 DA864169 DQ892692 ABM83618 DQ895955 ABM86881 X54637 CAA38449 XM_011528245 XP_011526547 XM_011528246 XP_011526548 XM_011528247 XP_011526549 XM_011528248 XP_011526550 XM_011528249 XP_011526551 XM_011528250 XP_011526552 XM_011528251 XP_011526553 XM_011528252 XP_011526554 NM_003331 NP_003322
Function Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. {ECO:0000269|PubMed:7526154}.
Tissue Specificity Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines. {ECO:0000269|PubMed:2156206}.
Top Pathways Jak-STAT signaling pathway, Toxoplasmosis, Hepatitis C, Osteoclast differentiation, Measles

Phospho-Tyk2 (Tyr1054/1055) Antibody - 9321 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or interferon-α treated for the indicated times, using Phospho-Tyk2 (Tyr1054/1055) Antibody (upper) or Tyk2 Antibody #9312 (lower).

Tyk2 Antibody - 9312 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Raji and Jurkat cells, using Tyk2 Antibody.

Tyk2 (D4I5T) Rabbit mAb - 14193 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4I5T
Western blot analysis of extracts from various cell lines using Tyk2 (D4I5T) Rabbit mAb.

Tyk 2 (C-20) - sc-169 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Tyk 2 (C-20): sc-169. Western blot analysis of Tyk 2 expression in NIH/3T3 mouse cells.

Tyk 2 (C-8) - sc-5271 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tyk 2 (C-8): sc-5271. Western blot analysis of Tyk 2 expression in Jurkat (A) and A-431 (B) whole cell lysates.

Tyk 2 (G-18) - sc-30671 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tyk 2 (G-18): sc-30671. Western blot analysis of Tyk 2 expression in MEG-01 whole cell lysate.

Tyk 2 (H-135) - sc-7205 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Tyk 2 (H-135): sc-7205. Western blot analysis of Tyk 2 expression in NIH/3T3 whole cell lysate.

Tyk 2 (K-18) - sc-30672 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tyk 2 (K-18): sc-30672. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing cytoplasmic staining of epidermal cells, keratinocytes, Langerhans cells and melanocytes.

Tyk 2 (H-4) - sc-166686 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tyk 2 (H-4): sc-166686. Western blot analysis of Tyk 2 expression in M1 whole cell lysate.

Tyk 2 (51) - sc-136265 from Santa Cruz Biotechnology

Host Mouse
Clonality Monoclonal
Tyk 2 (51): sc-136265. Western blot analysis of Tyk 2 expression in Jurkat whole cell lysate.

p-Tyk 2 (Tyr 1054/1055) - sc-11763 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Tyk 2 (Tyr 1054/1055)-R: sc-11763-R. Western blot analysis of Tyk 2 phosphoryaltion in Jurkat whole cell lysate.

p-Tyk 2 (Tyr 1054) - sc-135637 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Tyk 2 (Tyr 1054): sc-135637. Western blot analysis of phosphorylated Tyk 2 expression in untreated (A) and Anisomycin-treated (B) HT-29 cell extracts.

Anti-TYK2 (phospho Y292) antibody - ab138394 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TYK2 (phospho Y292) antibody (ab138394) at 1/500 dilution + 293 cell extract at 30 µg

Anti-TYK2 antibody - ab40718 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TYK2 antibody (ab40718) at 1 µg/mlLane 1 : MDA MB 361 (Human breast adenocarcinoma cell line) Whole Cell Lysate Lane 2 : Raji (Human Burkitt's lymphoma cell line) Whole Cell Lysate Lane 3 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-TYK2 antibody - ab57677 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
TYK2 antibody (ab57677) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human leiomyosarcoma.

Anti-TYK2 antibody - ab57678 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
TYK2 antibody (ab57678) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human lymphoma.

Anti-TYK2 antibody - ab39550 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using ab39550 (10-20µg/ml). Left: Untreated; Right: Treated with synthesized peptide.

Anti-TYK2 antibody - ab135866 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TYK2 antibody (ab135866) at 1/500 dilution + 293 cell extract at 30 µg

Anti-TYK2 antibody - ab108064 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TYK2 antibody (ab108064) at 1 µg/ml + COLO205 cell lysate at 10 µg

Anti-TYK2 antibody - ab115691 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115691 at 10ug/ml staining TYK2 in Human kidney tissue by immunohistochemistry (FFPE). Following primary incubation slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-TYK2 antibody [EP1127Y] - ab52645 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1127Y
Anti-TYK2 antibody [EP1127Y] (ab52645) at 1/50000 dilution + Raji cell lysate at 10 µgSecondaryGoat anti-Rabbit HRP labeled at 1/2000 dilution

Anti-TYK2 antibody - N-terminal - ab167101 from Abcam

Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TYK2 antibody - N-terminal (ab167101) at 1 µg/mlLane 2 : Anti-TYK2 antibody - N-terminal (ab167101) at 2 µg/mlLane 1 : Human small intestine tissue lysateLane 2 : Human small intestine tissue lysateLysates/proteins at 15 µg per lane.

Anti-TYK2 Antibody (aa249-396) - LS-C10924 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-TYK2 Antibody (phospho-Tyr1054/Tyr1055) - LS-C10925 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TYK2 Antibody (phospho-Tyr1054/Tyr1055) - LS-C10926 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Search more