| Gene Symbol |
CRTAM
|
| Entrez Gene |
56253
|
| Alt Symbol |
CD355
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytotoxic and regulatory T cell molecule
|
| Other Description |
class I MHC restricted T cell associated molecule|class-I MHC-restricted T cell associated molecule|class-I MHC-restricted T-cell-associated molecule|cytotoxic and regulatory T-cell molecule
|
| Swissprots |
Q6IRX2 O95727 Q59EI1
|
| Accessions |
CCF77045 EAW67532 O95727 AB209830 BAD93067 AF001622 AAC80267 AK293470 BAG56963 AK313578 BAG36349 BC070266 AAH70266 BX118379 CA309993 CK004240 DC305734 HQ447587 ADQ32073 XM_011542900 XP_011541202 NM_001304782 NP_001291711 NM_019604 NP_062550
|
| Function |
Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. {ECO:0000250|UniProtKB:Q149L7, ECO:0000269|PubMed:15811952}.
|
| Subcellular Location |
Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
|
| Tissue Specificity |
In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues. {ECO:0000269|PubMed:10811014, ECO:0000269|PubMed:15811952, ECO:0000269|PubMed:16300832}.
|
![Western Blot: CRTAM Overexpression Lysate (Adult Normal) [NBP2-06714] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CRTAM.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4800_CRTAM%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06714-img0001.jpg)