CYP51A1

Gene Symbol CYP51A1
Entrez Gene 1595
Alt Symbol CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1
Species Human
Gene Type protein-coding
Description cytochrome P450, family 51, subfamily A, polypeptide 1
Other Description CYPLI|cytochrome P450 51A1|cytochrome P450, 51 (lanosterol 14-alpha-demethylase)|cytochrome P450-14DM|cytochrome P45014DM|cytochrome P450LI|lanosterol 14-alpha demethylase|lanosterol 14-alpha-demethylase|sterol 14-alpha demethylase
Swissprots Q99868 B4DJ55 O00772 B2RAI4 Q16850 Q8N1A8 A4D1F8 O00770 Q16784
Accessions AAB46356 AAC50951 EAL24154 EAW76858 EAW76859 Q16850 AK295932 BAG58717 AK314205 BAG36881 BC018429 AAH18429 BC032322 AAH32322 D55653 BAA09512 DA349400 DC376300 DQ891311 ABM82237 DQ894495 ABM85421 U23942 AAB39951 NM_000786 NP_000777 NM_001146152 NP_001139624
Function Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. {ECO:0000269|PubMed:20149798}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}. Microsome membrane {ECO:0000305}.
Tissue Specificity Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung. {ECO:0000269|PubMed:8619637}.
Top Pathways Steroid biosynthesis