| Gene Symbol |
CYP51A1
|
| Entrez Gene |
1595
|
| Alt Symbol |
CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 51, subfamily A, polypeptide 1
|
| Other Description |
CYPLI|cytochrome P450 51A1|cytochrome P450, 51 (lanosterol 14-alpha-demethylase)|cytochrome P450-14DM|cytochrome P45014DM|cytochrome P450LI|lanosterol 14-alpha demethylase|lanosterol 14-alpha-demethylase|sterol 14-alpha demethylase
|
| Swissprots |
Q99868 B4DJ55 O00772 B2RAI4 Q16850 Q8N1A8 A4D1F8 O00770 Q16784
|
| Accessions |
AAB46356 AAC50951 EAL24154 EAW76858 EAW76859 Q16850 AK295932 BAG58717 AK314205 BAG36881 BC018429 AAH18429 BC032322 AAH32322 D55653 BAA09512 DA349400 DC376300 DQ891311 ABM82237 DQ894495 ABM85421 U23942 AAB39951 NM_000786 NP_000777 NM_001146152 NP_001139624
|
| Function |
Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. {ECO:0000269|PubMed:20149798}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000305}. Microsome membrane {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung. {ECO:0000269|PubMed:8619637}.
|
| Top Pathways |
Steroid biosynthesis
|