| Gene Symbol |
MSN
|
| Entrez Gene |
4478
|
| Alt Symbol |
HEL70
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
moesin
|
| Other Description |
epididymis luminal protein 70|membrane-organizing extension spike protein
|
| Swissprots |
P26038
|
| Accessions |
CAB46379 EAX05398 EAX05399 P26038 AK297165 BAH12513 AK308486 AK309354 AK309986 BC001112 AAH01112 BC011827 AAH11827 BC017293 AAH17293 CN386296 DQ892653 ABM83579 DQ895892 ABM86818 EU794636 ACJ13690 M69066 AAA36322 XM_005262269 XP_005262326 XM_011530959 XP_011529261 XM_011530960 XP_011529262 NM_002444 NP_002435
|
| Function |
Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. {ECO:0000269|PubMed:21549406}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Apical cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment. {ECO:0000250, ECO:0000269|PubMed:18586956}.
|
| Tissue Specificity |
In all tissues and cultured cells studied.
|
| Top Pathways |
Leukocyte transendothelial migration, Measles, Proteoglycans in cancer, Regulation of actin cytoskeleton
|
![Western Blot: Moesin Overexpression Lysate (Adult Normal) [NBL1-13334] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Moesin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5549_Moesin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13334-img0002.jpg)