CDH1

Gene Symbol	CDH1
Entrez Gene	999
Alt Symbol	Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Species	Human
Gene Type	protein-coding
Description	cadherin 1, type 1, E-cadherin (epithelial)
Other Description	CAM 120/80|E-Cadherin|cadherin 1, E-cadherin (epithelial)|cadherin-1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|epithelial cadherin|uvomorulin
Swissprots	Q14216 Q15855 Q9UII8 A8K1U7 P12830 Q4PJ14 Q16194 Q13799
Accessions	AAA21764 AAD14108 AAY68225 ADC53120 AKC34897 BAA08537 CAA84586 EAW83242 EAW83243 EAW83244 EAW83245 P12830 AB025105 BAA88956 AB025106 BAA88957 AI890107 AK290012 BAF82701 AK297913 BAG60232 AK309703 AK311198 AK312551 BAG35448 BC013851 BC141838 AAI41839 BC144283 BC146662 AAI46663 EU709494 ACD87624 L08599 AAA61259 X12790 CAA31279 X52279 CAA36522 Z13009 CAA78353 Z18923 CAA79356 XM_011523488 XP_011521790 XM_011523489 XP_011521791 NM_004360 NP_004351
Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000269|PubMed:16417575}.
Subcellular Location	Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
Tissue Specificity	Non-neural epithelial tissues.
Top Pathways	Rap1 signaling pathway, Adherens junction, Hippo signaling pathway, Bacterial invasion of epithelial cells, Thyroid cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

E-Cadherin (24E10) Rabbit mAb (Biotinylated) - 8834 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone 24E10

E-Cadherin (24E10) Rabbit mAb (Alexa Fluor ® 594 Conjugate) - 7687 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (50 tests) Host Rabbit Clonality Monoclonal Clone 24E10

E-Cadherin (24E10) Rabbit mAb (PE Conjugate) - 7559 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (50 tests) Host Rabbit Clonality Monoclonal Clone 24E10

E-Cadherin (24E10) Rabbit mAb (Alexa Fluor ® 555 Conjugate) - 4295 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (50 tests) Host Rabbit Clonality Monoclonal Clone 24E10

E-Cadherin (24E10) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 9835 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (50 tests) Host Rabbit Clonality Monoclonal Clone 24E10

E-Cadherin (24E10) Rabbit mAb (Pacific Blue™ Conjugate) - 8437 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (50 tests) Host Rabbit Clonality Monoclonal Clone 24E10

E-Cadherin (24E10) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 3199 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (50 tests) Host Rabbit Clonality Monoclonal Clone 24E10

PathScan ® EMT Duplex IF Kit - 7771 from Cell Signaling Technology Prices $459.00 Sizes 1 kit (100 tests) Clonality Polyclonal

E-Cadherin (4A2) Mouse mAb - 14472 from Cell Signaling Technology Prices $250.00 Sizes 100 µl (10 western blots) Host Mouse Clonality Monoclonal Clone 4A2

E-Cadherin (32A8) Mouse mAb - 5296 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Mouse Clonality Monoclonal Clone 32A8

Pan-Cadherin Antibody - 4068 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

E-Cadherin (24E10) Rabbit mAb - 3195 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone 24E10

Pan-Cadherin (28E12) Rabbit mAb - 4073 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone 28E12

E-Cadherin Antibody - 4065 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

E-cadherin (H-108) - sc-7870 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

E-cadherin (67A4) - sc-21791 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

E-cadherin (S-17) - sc-31020 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

E-cadherin (G-10) - sc-8426 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

E-cadherin (K-20) - sc-31021 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

E-cadherin (N-20) - sc-1500 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

E-cadherin (DECMA-1) - sc-59778 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rat Clonality Monoclonal

E-cadherin (5H9) - sc-52327 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

E-cadherin (2Q663) - sc-71008 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

E-cadherin (1.B.54) - sc-71009 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

E-cadherin (5F133) - sc-71007 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

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