CDH1

Gene Symbol	CDH1
Entrez Gene	999
Alt Symbol	Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Species	Human
Gene Type	protein-coding
Description	cadherin 1, type 1, E-cadherin (epithelial)
Other Description	CAM 120/80|E-Cadherin|cadherin 1, E-cadherin (epithelial)|cadherin-1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|epithelial cadherin|uvomorulin
Swissprots	Q14216 Q15855 Q9UII8 A8K1U7 P12830 Q4PJ14 Q16194 Q13799
Accessions	AAA21764 AAD14108 AAY68225 ADC53120 AKC34897 BAA08537 CAA84586 EAW83242 EAW83243 EAW83244 EAW83245 P12830 AB025105 BAA88956 AB025106 BAA88957 AI890107 AK290012 BAF82701 AK297913 BAG60232 AK309703 AK311198 AK312551 BAG35448 BC013851 BC141838 AAI41839 BC144283 BC146662 AAI46663 EU709494 ACD87624 L08599 AAA61259 X12790 CAA31279 X52279 CAA36522 Z13009 CAA78353 Z18923 CAA79356 XM_011523488 XP_011521790 XM_011523489 XP_011521791 NM_004360 NP_004351
Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000269|PubMed:16417575}.
Subcellular Location	Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
Tissue Specificity	Non-neural epithelial tissues.
Top Pathways	Rap1 signaling pathway, Adherens junction, Hippo signaling pathway, Bacterial invasion of epithelial cells, Thyroid cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human E Cadherin peptide - ab87418 from Abcam Category Peptide

Human E Cadherin protein fragment - ab38254 from Abcam Category Protein Source E. coli Species Human

Human E Cadherin protein fragment - ab174084 from Abcam Category Protein Source HEK 293 cells Species Human

CDH1 / E Cadherin Antibody Blocking Peptide - LS-E3579 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDH1 / E Cadherin Antibody Blocking Peptide - LS-E3580 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDH1 / E Cadherin Antibody Blocking Peptide - LS-E27795 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDH1 / E Cadherin Antibody Blocking Peptide - LS-E18465 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDH1 / E Cadherin Antibody Blocking Peptide - LS-E21677 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDH1 / E Cadherin Antibody Blocking Peptide - LS-E21676 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

E-Cadherin Recombinant Protein - H00000999-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human E-Cadherin Protein - H00000999-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

E-Cadherin Peptide - P0459 from Novus Biologicals Category Peptide Species Human

E-Cadherin Peptide - P0458 from Novus Biologicals Category Peptide Species Human

E-Cadherin Recombinant Protein - H00000999-G01 from Novus Biologicals Category Protein Prices $549.00 Sizes 2 µg Species Human

E-Cadherin-CDH1-Antibody-C-term-Blocking-peptide - BP1477b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

E-Cadherin-CDH1-Antibody-N-term-Blocking-peptide - BP1477a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human E-Cadherin Fc Chimera, CF - 648-EC-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human E-Cadherin, CF - 8505-EC-050 from R&D Systems Category Protein Source Human embryonic kidney cell, HEK293-derived, Asp155-Ile707, with a C-terminal 6-His tag

Cadherin-E Protein (OPPA01367) - OPPA01367 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

Human CDH1 His tag protein - orb83261 from Biorbyt Category Protein Prices $638.00, $978.00 Sizes 100 μg, 200 μg Source Human Species Human

Human CDH1 protein - orb138510 from Biorbyt Category Protein Prices $323.00, $527.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Human E-Cadherin (His Tag) protein - orb232217 from Biorbyt Category Protein Prices $281.00, $527.00 Sizes 20 μg, 100 μg Species Human

CDH1 peptide - orb217061 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

E-cadherin peptide - orb72630 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

CDH1 Blocking Peptide - 33R-7525 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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