NXF1

Gene Symbol NXF1
Entrez Gene 10482
Alt Symbol MEX67, TAP
Species Human
Gene Type protein-coding
Description nuclear RNA export factor 1
Other Description mRNA export factor TAP|tip associating protein|tip-associated protein|tip-associating protein
Swissprots Q99799 B4E269 Q9UQL2 Q9UBU9
Accessions EAW74103 EAW74104 EAW74105 EAW74106 EAW74107 Q9UBU9 AB209915 BAD93152 AF112880 AAD39102 AF126246 AAD20016 AJ132712 CAA10753 AK027192 AK304082 BAG64989 AK304137 BAG65031 AK304743 BAG65502 AK307961 AK307998 AV750251 AW005685 BC004904 AAH04904 BC017421 BC028041 AAH28041 BM751313 CR749674 CAH18465 DB141140 DQ892931 ABM83857 DQ896180 ABM87179 U80073 AAB81111 NM_001081491 NP_001074960 NM_006362 NP_006353
Function Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. {ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:9660949}.
Subcellular Location Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles.
Tissue Specificity Expressed ubiquitously.
Top Pathways RNA transport, mRNA surveillance pathway, Ribosome biogenesis in eukaryotes, Influenza A, Herpes simplex infection

NXF1 (D5X4G) Rabbit mAb - 12735 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5X4G
Western blot analysis of extracts from various cell lines using NXF1 (D5X4G) Rabbit mAb.

TAP (D-9) - sc-365576 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TAP (D-9): sc-365576. Western blot analysis of TAP expression in HeLa nuclear extract.

TAP (G-12) - sc-28377 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TAP (G-12): sc-28377. Western blot analysis of TAP expression in HeLa (A), A-431 (B), Jurkat (C) and K-562 (D) nuclear extracts.

TAP (H-120) - sc-25768 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TAP (H-120): sc-25768. Western blot analysis of TAP expression in non-transfected: sc-117752 (A) and human TAP transfected: sc-114751 (B) 293T whole cell lysates.

TAP (N-19) - sc-17310 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TAP (N-19): sc-17310. Western blot analysis of TAP expression in HeLa (A), A-673 (B), K-562 (C) and Jurkat (D) nuclear extracts.

TAP (R-20) - sc-17311 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TAP (R-20): sc-17311. Western blot analysis of TAP expression in Hela nuclear extract.

TAP (53H8) - sc-32319 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TAP (53H8): sc-32319. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

TAP (31) - sc-136095 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
TAP (31): sc-136095. Western blot analysis of TAP expression in Jurkat whole cell lysate.

Anti-NXF1 antibody - ab96078 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-NXF1 antibody (ab96078) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-NXF1 antibody - ab97922 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NXF1 antibody (ab97922) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : MOLT4 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-NXF1 antibody - ab137216 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NXF1 antibody (ab137216) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-NXF1 antibody - ab199288 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NXF1 antibody (ab199288) at 1/500 dilutionLane 1 : HeLa cell lysateLane 2 : K562 cell lysate

Anti-NXF1 antibody [53H8] - ab50609 from Abcam

Prices $380.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 53H8
Anti-NXF1 antibody [53H8] (ab50609) at 0.5 µg/ml + Hela nuclear cell extract at 200 µg/ml

Anti-NXF1 antibody [EPR8009] - ab129160 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8009
All lanes : Anti-NXF1 antibody [EPR8009] (ab129160) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : 293T cell lysateLane 3 : K562 cell lysateLane 4 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-NXF1 antibody [EPR8010] - ab129171 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8010
All lanes : Anti-NXF1 antibody [EPR8010] (ab129171) at 1/1000 dilutionLane 1 : K562 cell lysates Lane 2 : HeLa cell lysates Lane 3 : 293T cell lysates Lysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti-Rabbit IgG at 1/2000 dilution

Anti-NXF1 / TAP Antibody (aa1-151) - LS-C185462 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded NCIN87 Xenograft using TAP antibody at 1:100 dilution.

Anti-NXF1 / TAP Antibody (aa449-619) - LS-C185459 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of paraformaldehyde-fixed HeLa using TAP antibody at 1:200 dilution.

Anti-NXF1 / TAP Antibody (clone 53H8) - LS-C82236 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 53H8

Anti-NXF1 / TAP Antibody (aa78-127) - LS-C30479 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-NXF1 / TAP Antibody (N-Terminus) - LS-C31714 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
NXF1 antibody LS-C31714 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-NXF1 / TAP Antibody (aa1-30, APC) - LS-C216157 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NXF1 / TAP Antibody (aa1-30, AP) - LS-C216156 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NXF1 / TAP Antibody (aa8-57) - LS-C200293 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HeLa cells using NXF1 antibody.

Anti-NXF1 / TAP Antibody (aa1-30, Biotin) - LS-C216158 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NXF1 / TAP Antibody (aa1-30, PE) - LS-C216160 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more