NXF1

Gene Symbol	NXF1
Entrez Gene	10482
Alt Symbol	MEX67, TAP
Species	Human
Gene Type	protein-coding
Description	nuclear RNA export factor 1
Other Description	mRNA export factor TAP|tip associating protein|tip-associated protein|tip-associating protein
Swissprots	Q99799 B4E269 Q9UQL2 Q9UBU9
Accessions	EAW74103 EAW74104 EAW74105 EAW74106 EAW74107 Q9UBU9 AB209915 BAD93152 AF112880 AAD39102 AF126246 AAD20016 AJ132712 CAA10753 AK027192 AK304082 BAG64989 AK304137 BAG65031 AK304743 BAG65502 AK307961 AK307998 AV750251 AW005685 BC004904 AAH04904 BC017421 BC028041 AAH28041 BM751313 CR749674 CAH18465 DB141140 DQ892931 ABM83857 DQ896180 ABM87179 U80073 AAB81111 NM_001081491 NP_001074960 NM_006362 NP_006353
Function	Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. {ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:9660949}.
Subcellular Location	Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles.
Tissue Specificity	Expressed ubiquitously.
Top Pathways	RNA transport, mRNA surveillance pathway, Ribosome biogenesis in eukaryotes, Influenza A, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NXF1 full length protein - ab153087 from Abcam Category Protein Source Wheat germ Species Human

Human NXF1 protein fragment - ab153088 from Abcam Category Protein Source Wheat germ Species Human

NXF1 / TAP Antibody Blocking Peptide - LS-E3364 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NXF1 / TAP Antibody Blocking Peptide - LS-E14869 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human NXF1 Protein - H00010482-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NXF1 Recombinant Protein - H00010482-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NXF1-Antibody-N-term-Blocking-Peptide - BP14539a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NXF1 Blocking Peptide - 33R-8098 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NXF1 Blocking Peptide - 33R-5618 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NXF1 Blocking Peptide - abx063683 from Abbexa Category Peptide Species Human, Monkey

NXF1 - H00010482-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NXF1 - H00010482-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NXF1 - H00010482-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NXF1 - H00010482-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NXF1 fusion protein - ag0413 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human NXF1, GST-tagged - NXF1-1427H from Creative Biomart Category Protein Source E.coli Species Human

NXF1 Blocking Peptide - CBP2489 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

Recombinant Human Nuclear RNA export factor 1(NXF1) - CSB-YP016218HU CSB-EP016218HU CSB-BP016218HU CSB-MP016218HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Nuclear RNA Export Factor 1 (NXF1) - RPC208Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

NXF1 Antibody - SH-A14183 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

NXF1 Recombinant Protein Antigen - NBP2-49341PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

NXF1 Peptide, Human - M34GP10759H from Creative Peptides Category Peptide Source Synthetic. Species Human

Nuclear RNA Export Factor 1, Recombinant Protein - MBS2033024 from MyBioSource Category Protein Prices $175.00, $365.00, $565.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Rat

Nuclear RNA export factor 1 (NXF1), Recombinant Protein - MBS1376978 from MyBioSource Category Protein Prices $1,415.00, $1,415.00, $1,640.00, $1,640.00, $2,385.00, $2,385.00, $2,830.00, $2,830.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

NXF1 fusion protein - Ag27329 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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