CDC20

Gene Symbol CDC20
Entrez Gene 991
Alt Symbol CDC20A, bA276H19.3, p55CDC
Species Human
Gene Type protein-coding
Description cell division cycle 20
Other Description CDC20 cell division cycle 20 homolog|cell division cycle 20 homolog|cell division cycle protein 20 homolog
Swissprots Q12834 Q9BW56 B2R6Z6 Q9UQI9 D3DPJ1 Q5JUY4
Accessions ABE96834 EAX07101 EAX07102 Q12834 AF099644 AAD16405 AK225504 AK302539 BAG63811 AK303844 BAG64787 AK312780 BAG35643 BC000624 AAH00624 BC001088 AAH01088 BC006272 AAH06272 BC009425 AAH09425 BC009426 AAH09426 BC010044 AAH10044 BC012803 AAH12803 BC012827 AAH12827 BC013303 AAH13303 BC015998 AAH15998 BC024257 AAH24257 BC031294 AAH31294 BC110321 AAI10322 BT007388 AAP36052 DQ892290 ABM83216 DQ895489 ABM86415 EU831627 ACE87227 EU831712 ACE86546 U05340 AAA19017 NM_001255 NP_001246
Function Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. {ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20034488}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20034488}.
Top Pathways Cell cycle, Ubiquitin mediated proteolysis, Oocyte meiosis, HTLV-I infection, Viral carcinogenesis

Phospho-CDC20 (Ser51) Antibody - 8038 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293T cells, untreated (-) or treated (+) with λ phosphatase, using Phospho-CDC20 (Ser51) Antibody (upper) and CDC20 Antibody #4823 (lower).

CDC20 (D6C2Q) Rabbit mAb - 14866 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6C2Q
Western blot analysis of extracts from various cell lines using CDC20 (D6C2Q) Rabbit mAb.

CDC20 Antibody - 4823 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using CDC20 Antibody.

p55 CDC (C-19) - sc-1906 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p55 CDC (C-19): sc-1906. Western blot analysis of p55 CDC expression in Ramos (A) and U-937 (B) whole cell lysates.

p55 CDC (AR12) - sc-53398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p55 CDC (AR12): sc-53398. Western blot analysis of p55 CDC expression in HeLa (A), Nocodazole treated HeLa (B) and Ramos (C) whole cell lysates.

p55 CDC (E-7) - sc-13162 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p55 CDC (E-7): sc-13162. Immunoperoxidase staining of formalin fixed, paraffin-embedded human malignant lymphoma showing nuclear and cytoplasmic staining of tumor cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

p55 CDC (H-175) - sc-8358 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p55 CDC siRNA (h): sc-36160. Western blot analysis of p55 CDC expression in non-transfected control (A) and p55 CDC siRNA transfected (B) HeLa cells. Blot probed with p55 CDC (H-175): sc-8358. GAPDH (FL-335): sc-25778 used as specificity and loading control.

p55 CDC (N-19) - sc-1907 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p55 CDC (N-19): sc-1907. Western blot analysis of p55 CDC expression in K-562 (A), MOLT-4 (B), Ramos (C), U-937 (D) and NIH/3T3 (E) whole cell lysates.

p55 CDC (H-7) - sc-5296 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p55 CDC (H-7): sc-5296. Western blot analysis of p55 CDC expression in KNRK whole cell lysate.

p55 CDC (41) - sc-136024 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
p55 CDC (41): sc-136024. Western blot analysis of p55 CDC expression in Jurkat whole cell lysate.

Anti-Cdc20 antibody - ab26483 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cdc20 antibody (ab26483) at 1 µg/mlLane 1 : Raji (Human Burkitt's lymphoma cell line) Whole Cell Lysate (ab7908)Lane 2 : THP1 (Human acute monocytic leukemia cell line) Whole Cell Lysate (ab7913)Lane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate (ab7902)Lane 4 : HL60 (Human promyelocytic leukemia cell line) Whole Cell Lysate (Human) Whole Cell Lysate (ab7914)Lysates/proteins at 20 µg per lane.SecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilutionPerformed under reducing conditions.

Anti-Cdc20 antibody - ab183479 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cdc20 antibody (ab183479) at 1/2000 dilutionLane 1 : U2OS cells transfected with control si RNALane 2 : U2OS cells transfected with Cdc20 si RNALane 3 : Rat INS1 cell lysateLane 4 : Mouse NIH 3T3 cell lysateLysates/proteins at 40 µg per lane.

Anti-Cdc20 antibody - ab64877 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cdc20 antibody (ab64877) at 1/500 dilutionLane 1 : extract from HeLa cells, (5-30µg total protein).Lane 2 : extract from Jurkat cells, (5-30µg total protein).Lane 3 : extract from Jurkat cells, (5-30µg total protein) and 5-10µg of the immunising peptide.

Anti-Cdc20 antibody - ab185814 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of HeLa cells using ab185814. Blue DAPI for nuclear staining.

Anti-Cdc20 antibody - ab72202 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling Cdc20 with ab72202 at 1/1000 (1µg/ml). Detection: DAB.

Anti-Cdc20 antibody - ab86104 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab86104, at 1/250 dilution, staining Cdc20 in formalin-fixed, paraffin-embedded human breast carcinoma tissue by Immunohistochemistry using DAB staining.

Anti-Cdc20 antibody [AR12] - ab190711 from Abcam

Prices $373.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone AR12

Anti-Cdc20 antibody [BA8] - ab18217 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone BA8
Overlay histogram showing LoVo cells stained with ab18217 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab18217, 1µg/1x106 cells) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2a [ICIGG2A] (ab91361, 1µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.

Anti-CDC20 Antibody (C-Terminus) - LS-C5899 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CDC20 Antibody (C-Terminus) - LS-C18968 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDC20 Antibody (aa50-100) - LS-C78941 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CDC20 Antibody (C-Terminus, clone B-A8) - LS-C49038 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-A8

Anti-CDC20 Antibody - LS-C78942 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CDC20 Antibody - LS-C128049 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDC20 Antibody (N-Terminus, AP) - LS-C221709 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more