| Gene Symbol | CDC20 |
|---|---|
| Entrez Gene | 991 |
| Alt Symbol | CDC20A, bA276H19.3, p55CDC |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell division cycle 20 |
| Other Description | CDC20 cell division cycle 20 homolog|cell division cycle 20 homolog|cell division cycle protein 20 homolog |
| Swissprots | Q12834 Q9BW56 B2R6Z6 Q9UQI9 D3DPJ1 Q5JUY4 |
| Accessions | ABE96834 EAX07101 EAX07102 Q12834 AF099644 AAD16405 AK225504 AK302539 BAG63811 AK303844 BAG64787 AK312780 BAG35643 BC000624 AAH00624 BC001088 AAH01088 BC006272 AAH06272 BC009425 AAH09425 BC009426 AAH09426 BC010044 AAH10044 BC012803 AAH12803 BC012827 AAH12827 BC013303 AAH13303 BC015998 AAH15998 BC024257 AAH24257 BC031294 AAH31294 BC110321 AAI10322 BT007388 AAP36052 DQ892290 ABM83216 DQ895489 ABM86415 EU831627 ACE87227 EU831712 ACE86546 U05340 AAA19017 NM_001255 NP_001246 |
| Function | Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. {ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20034488}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20034488}. |
| Top Pathways | Cell cycle, Ubiquitin mediated proteolysis, Oocyte meiosis, HTLV-I infection, Viral carcinogenesis |