UBE2N

Gene Symbol	UBE2N
Entrez Gene	7334
Alt Symbol	HEL-S-71, UBC13, UBCHBEN; UBC13, UbcH-ben, UbcH13
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2N
Other Description	bendless-like ubiquitin conjugating enzyme|bendless-like ubiquitin-conjugating enzyme|epididymis secretory protein Li 71|ubiquitin carrier protein N|ubiquitin-conjugating enzyme E2 N|ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)|ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)|ubiquitin-protein ligase N|yeast UBC13 homolog
Swissprots	Q53Y81 P61088
Accessions	EAW97480 EAW97481 EAW97482 P61088 AK098233 AL110140 BC000396 AAH00396 BC003365 AAH03365 BC108704 AAI08705 BI459891 BT006873 AAP35519 CB243041 D83004 BAA11675 DQ896763 ABM87762 EU176463 ABW03914 EU176466 ABW03917 FJ224354 ACI46046 XM_011538719 XP_011537021 XR_944704 XR_944705 XR_944706 XR_944707 NM_003348 NP_003339
Function	The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the
Subcellular Location	Nucleus {ECO:0000269|PubMed:19340006}. Cytoplasm {ECO:0000269|PubMed:19340006}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UBE2N (D2A1) Rabbit mAb - 6999 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D2A1

Ubc13 Antibody - 4919 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

UBC13 (F-10) - sc-376470 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

UBC13 (H-75) - sc-292618 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

UBC13/UBE2NL (N-20) - sc-19542 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

UBC13/UBE2NL (C-9) - sc-365722 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

UBC13 (L-22) - sc-134137 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

UBE2N (4E11) - sc-58452 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-Ube2N / Ubc13 antibody - ab25885 from Abcam Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Ube2N / Ubc13 antibody [4E11] - ab38795 from Abcam Prices $378.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 4E11

Anti-Ube2N / Ubc13 antibody [EPR5162] - ab109286 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5162

Anti-Ube2N / Ubc13 antibody [EPR5163] - ab109294 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5163

Anti-UBE2N / UBC13 Antibody (aa1-153, Azide-free) - LS-C330722 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-UBE2N / UBC13 Antibody (C-Terminus) - LS-C80044 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-UBE2N / UBC13 Antibody (aa40-51) IHC-plus™ - LS-B433 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-UBE2N / UBC13 Antibody (Internal, clone EPR5163) - LS-C138370 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5163

Anti-UBE2N / UBC13 Antibody (clone 4C11-G11) - LS-C198399 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4C11-G11

Anti-UBE2N / UBC13 Antibody (Internal, clone EPR5162) - LS-C138283 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5162

Anti-UBE2N / UBC13 Antibody (C-Terminus) IHC-plus™ - LS-B1433 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-UBE2N / UBC13 Antibody - LS-C10935 from LifeSpan Bioscience Prices $495.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-UBE2N / UBC13 Antibody (aa2-19) - LS-C838 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-UBE2N / UBC13 Antibody - LS-C26908 from LifeSpan Bioscience Prices $360.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-UBE2N / UBC13 Antibody (aa80-129) - LS-C30574 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-UBE2N / UBC13 Antibody (C-Terminus) - LS-C122520 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

UBE2N/Ubc13 Antibody - NBP1-54894 from Novus Biologicals Prices $139.00, $299.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

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