UBE2N

Gene Symbol	UBE2N
Entrez Gene	7334
Alt Symbol	HEL-S-71, UBC13, UBCHBEN; UBC13, UbcH-ben, UbcH13
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2N
Other Description	bendless-like ubiquitin conjugating enzyme|bendless-like ubiquitin-conjugating enzyme|epididymis secretory protein Li 71|ubiquitin carrier protein N|ubiquitin-conjugating enzyme E2 N|ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)|ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)|ubiquitin-protein ligase N|yeast UBC13 homolog
Swissprots	Q53Y81 P61088
Accessions	EAW97480 EAW97481 EAW97482 P61088 AK098233 AL110140 BC000396 AAH00396 BC003365 AAH03365 BC108704 AAI08705 BI459891 BT006873 AAP35519 CB243041 D83004 BAA11675 DQ896763 ABM87762 EU176463 ABW03914 EU176466 ABW03917 FJ224354 ACI46046 XM_011538719 XP_011537021 XR_944704 XR_944705 XR_944706 XR_944707 NM_003348 NP_003339
Function	The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the
Subcellular Location	Nucleus {ECO:0000269|PubMed:19340006}. Cytoplasm {ECO:0000269|PubMed:19340006}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ube2N / Ubc13 + UBE2V1 protein complex, Chemical Free - ab81567 from Abcam Category Protein Source E. coli Species Human

Human Ube2N / Ubc13 full length protein - ab105634 from Abcam Category Protein Source E. coli Species Human

Human Ube2N / Ubc13 full length protein - ab95900 from Abcam Category Protein Source E. coli Species Human

Human Ube2N / Ubc13 peptide - ab39894 from Abcam Category Peptide Species Human

Ube2N / Ubc13 protein (Active) - ab127413 from Abcam Category Protein Source E. coli Species Yeast

Ube2N / Ubc13 protein (Human) - ab127400 from Abcam Category Protein Source E. coli Species Human

UBE2N / UBC13 Antibody Blocking Peptide - LS-E30085 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

UBE2N / UBC13 Antibody Blocking Peptide - LS-E12051 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2N / UBC13 Antibody Blocking Peptide - LS-E11675 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2N/Ubc13 Recombinant Protein - H00007334-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UBE2N/Ubc13 Peptide - NBP1-96768 from Novus Biologicals Category Peptide Prices $169.00 Sizes 50 µg

UBE2N/Ubc13 Blocking Peptide - NBP1-76593PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human UBE2N/Ubc13 Protein - NBP1-51063 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

UBE2N/Ubc13 Peptide - P0904 from Novus Biologicals Category Peptide Species Human

UBE2N-Antibody-N-term-Blocking-peptide - BP13846a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBE2N-Antibody-N-term-Blocking-Peptide - BP2125a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-UBE2N (Ubc13)/Uev1a Complex, CF - E2-664-100 from R&D Systems Category Protein Source E. coli-derived, Contains an terminal 6-His tag

UbiCREST Enzyme Set Protein - K-400 from R&D Systems Category Protein Prices $439.00 Sizes 1 kit

UBE2N Protein (OPPA00011) - OPPA00011 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human UBE2N protein - orb169512 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

UBE2N Blocking Peptide - 33R-9466 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBE2N Blocking Peptide - 33R-3532 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBE2N protein (His tag) - 80R-1751 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

UBE2N / BLU (1-152, His-tag) - AR09933PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

UBE2N / BLU (1-152, His-tag) - AR09933PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

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