CAMK4

Gene Symbol	CAMK4
Entrez Gene	814
Alt Symbol	CaMK IV, CaMK-GR, IV, caMK
Species	Human
Gene Type	protein-coding
Description	calcium/calmodulin-dependent protein kinase IV
Other Description	CAM kinase IV|CAM kinase- GR|brain Ca(2+)-calmodulin-dependent protein kinase type IV|brain Ca++-calmodulin-dependent protein kinase type IV|caM kinase-GR|calcium/calmodulin-dependent protein kinase type IV|calcium/calmodulin-dependent protein kinase type IV catalytic chain
Swissprots	Q16566 D3DSZ7
Accessions	EAW49032 EAW49033 EAW49034 Q16566 AK311662 AK312840 BAG35694 AL833368 BC016695 AAH16695 BC025687 AAH25687 BG721313 D30742 BAA06403 DA396146 DQ892902 ABM83828 DQ893195 ABM84121 DQ893196 ABM84122 DQ896523 ABM87522 DQ896524 ABM87523 DQ896525 ABM87524 DQ896526 ABM87525 L17000 AAA35639 L24959 AAA18251 XR_948301 XR_948302 XR_948303 NM_001744 NP_001735
Function	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MA
Subcellular Location	Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. {ECO:0000269|PubMed:12065094, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8397199}.
Top Pathways	cAMP signaling pathway, Long-term potentiation, Oxytocin signaling pathway, Alcoholism, Amphetamine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CamKII gamma full length protein - ab132986 from Abcam Category Protein Prices $410.00 Sizes 10 µg Source Wheat germ Species Human

Active human CamKII gamma protein fragment - ab63189 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

CAMKIV peptide - ab5859 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human CAMKIV full length protein - ab119450 from Abcam Category Protein Prices $402.00 Sizes 50 µg Source E. coli Species Human

Human CAMKIV full length protein - ab60756 from Abcam Category Protein Prices $288.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

CAMK4 / CaMK IV Antibody Blocking Peptide - LS-E3885 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CAMK4 / CaMK IV Antibody Blocking Peptide - LS-E22436 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CAMK4 / CaMK IV Antibody Blocking Peptide - LS-E22437 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CAMK4 / CaMK IV Antibody Blocking Peptide - LS-E13283 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CAMK4 / CaMK IV Antibody Blocking Peptide - LS-E13284 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CaMKIV Recombinant Protein - H00000814-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CaMKIV Partial Recombinant Protein - H00000814-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CaMKIV Recombinant Protein - P4223 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

CaMKIV Recombinant Protein - P3848 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

CaMKIV Protein - NBP1-99487 from Novus Biologicals Category Protein Prices $309.00 Sizes 5 µg

Recombinant Human CaMKIV Protein - NBP1-78878 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E. coli Species Human

CAMK4-Antibody-Center-H353-Blocking-Peptide - BP7211c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CAMK1d (Active) recombinant protein - GTX65290 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

CaMKIV (Active) recombinant protein - GTX65023 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Human CAMK4 GST tag protein - orb84092 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Insect Species Human

Human CAMK4 protein - orb168036 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

CAMK1d protein - 30R-2828 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

CAMK4 Blocking Peptide - 33R-9613 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CAMK4 protein - 30R-2854 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

CAMK4 protein (His tag) - 80R-2121 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

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