CAMK4

Gene Symbol	CAMK4
Entrez Gene	814
Alt Symbol	CaMK IV, CaMK-GR, IV, caMK
Species	Human
Gene Type	protein-coding
Description	calcium/calmodulin-dependent protein kinase IV
Other Description	CAM kinase IV|CAM kinase- GR|brain Ca(2+)-calmodulin-dependent protein kinase type IV|brain Ca++-calmodulin-dependent protein kinase type IV|caM kinase-GR|calcium/calmodulin-dependent protein kinase type IV|calcium/calmodulin-dependent protein kinase type IV catalytic chain
Swissprots	Q16566 D3DSZ7
Accessions	EAW49032 EAW49033 EAW49034 Q16566 AK311662 AK312840 BAG35694 AL833368 BC016695 AAH16695 BC025687 AAH25687 BG721313 D30742 BAA06403 DA396146 DQ892902 ABM83828 DQ893195 ABM84121 DQ893196 ABM84122 DQ896523 ABM87522 DQ896524 ABM87523 DQ896525 ABM87524 DQ896526 ABM87525 L17000 AAA35639 L24959 AAA18251 XR_948301 XR_948302 XR_948303 NM_001744 NP_001735
Function	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MA
Subcellular Location	Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. {ECO:0000269|PubMed:12065094, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8397199}.
Top Pathways	cAMP signaling pathway, Long-term potentiation, Oxytocin signaling pathway, Alcoholism, Amphetamine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CaMKIV CRISPR/Cas9 KO Plasmid (h) - sc-400806 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CaMKIV HDR Plasmid (h) - sc-400806-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CaMKIV Double Nickase Plasmid (h) - sc-400806-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CaMKIV Double Nickase Plasmid (h2) - sc-400806-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CaMKIV CRISPR Activation Plasmid (h) - sc-400806-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CaMKIV CRISPR Activation Plasmid (h2) - sc-400806-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CaMKIV Lentiviral Activation Particles (h) - sc-400806-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CaMKIV Lentiviral Activation Particles (h2) - sc-400806-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CaMKIV siRNA (h) - sc-29902 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CaMKIV shRNA Plasmid (h) - sc-29902-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CaMKIV shRNA (h) Lentiviral Particles - sc-29902-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CaMKIV RNAi - H00000814-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU119241 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0261 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0262 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0263 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN5321 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5321 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CAMK4 siRNA (Human) - CRH0568 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CaMKIV RNAi - H00000814-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CAMK4 - MBS8238392 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CAMK4 (NM_001744.4) - SHH254057 from Creative biogene Category siRNA Species Reactivities Human

CAMK4 shRNA Plasmid (Human) - CHH0568 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CAMK4 miRNA 3'UTR clone - MiUTR3H-00307 from Creative biogene Species Reactivities Human

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