CTNNB1

Gene Symbol CTNNB1
Entrez Gene 1499
Alt Symbol CTNNB, MRD19, armadillo
Species Human
Gene Type protein-coding
Description catenin (cadherin-associated protein), beta 1, 88kDa
Other Description catenin beta-1
Swissprots Q8NEW9 P35222 Q9H391 A8K1L7 Q8NI94
Accessions AAD32267 AAL89457 AAR18817 ACD11099 ACD11101 AEW16366 CCH22596 EAW64625 EAW64626 EAW64627 EAW64628 P35222 AB062292 BAB93475 AB451264 BAG70078 AB451392 BAG70206 AK095242 AK289932 BAF82621 AK294778 BAG57905 AK296790 BAG59368 AK299954 BAG61781 AK314776 BC058926 AAH58926 BX648430 DA216720 EU446854 ABZ92383 U38440 X87838 CAA61107 Z19054 CAA79497 XM_005264886 XP_005264943 XM_006712983 XP_006713046 XM_006712984 XP_006713047 XM_006712985 XP_006713048 NM_001098209 NP_001091679 NM_001098210 NP_001091680 NM_001904 NP_001895
Function Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:212
Subcellular Location Cytoplasm. Nucleus {ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane {ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell
Tissue Specificity Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). {ECO:0000269|PubMed:11703283, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17289029}.
Top Pathways Proteoglycans in cancer, HTLV-I infection, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

PathScan ® Total β-Catenin Sandwich ELISA Kit - 7308 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)
Figure 1: Nonphospho- and phospho-β-catenin proteins from untreated and Calyculin A-treated 293 cells can be detected by PathScan® Total β-Catenin Sandwich ELISA kit #7308 with similar optical density readings. OD 450 readings are shown in the top figure, while the corresponding Western blot using Phospho-β-Catenin (Ser45) Antibody #9564 (right panel) or β-Catenin Antibody #9562 (left panel), is shown in the bottom figure.

PathScan ® Total β-Catenin Sandwich ELISA Antibody Pair - 7309 from Cell Signaling Technology

Category Antibody Pair

beta Catenin pSer45 + Total PhosphoTracer ELISA Kit - ab119656 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
Using Western blot, beta-catenin phosphorylation at Ser45 is detected in PMA/calyculin-treated A549 cells (+), compared with untreated A549 cells (-).

beta-Catenin (pS45) PhosphoTracer ELISA Kit - ab119619 from Abcam

Category ELISA Kit
Sensitivity 10000 cells/well
Range 10000 cells/well - 100000 cells/well
Using Western blot, beta-catenin phosphorylation at Ser45 is detected in PMA/calyculin-treated A549 cells (+), compared with untreated A549 cells (-).

beta-Catenin Total PhosphoTracer ELISA Kit - ab119620 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
Sensitivity 2000 cells/well
Range 2000 cells/well - 100000 cells/well
PhosphoTracer beta-Catenin Total ELISA Kit (ab119620) used in Sandwich ELISA.

Human CTNNB1 / Beta Catenin ELISA Kit (Sandwich ELISA) - LS-F4396 from LifeSpan Bioscience

Category ELISA Kit
Prices $690.00
Sizes 1 plate
Sensitivity 6.7 pg/ml
Range 31.2-2000 pg/ml

Mouse CTNNB1 / Beta Catenin ELISA Kit (Sandwich ELISA) - LS-F4891 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity 5.9 pg/ml
Range 31.2-2000 pg/ml

Mouse/Human/Rat Phospho-CTNNB1 / Beta Catenin (Tyr654) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1329 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 31.2-2000 pg/ml

Mouse/Human/Rat CTNNB1 / Beta Catenin ELISA Kit (Cell-Based ELISA) - LS-F1859 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 31.2-2000 pg/ml

Mouse/Human/Rat Phospho-CTNNB1 / Beta Catenin (Ser37) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1460 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 31.2-2000 pg/ml

Mouse/Human/Rat Phospho-CTNNB1 / Beta Catenin (Thr41, Ser45) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1461 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 31.2-2000 pg/ml

Mouse/Human/Rat Phospho-CTNNB1 / Beta Catenin (Tyr489) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1652 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 31.2-2000 pg/ml

Rat CTNNB1 / Beta Catenin ELISA Kit (Sandwich ELISA) - LS-F7875 from LifeSpan Bioscience

Category ELISA Kit
Prices $740.00
Sizes 1 plate
Sensitivity 31.2 pg/ml
Range 31.2-2000 pg/ml

Human CTNNB1 / Beta Catenin ELISA Kit (Sandwich ELISA) - LS-F11242 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.312 ng/ml
Range 31.2-2000 pg/ml

Rat CTNNB1 / Beta Catenin ELISA Kit (Sandwich ELISA) - LS-F11243 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.156
Range 31.2-2000 pg/ml

Rabbit anti-Beta-catenin Antibody, Affinity Purified - PLA0230 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunohistochemistry</B><BR/>Rabbit Anti-Beta-catenin Antibody, Affinity Purified: <B>Cat. No. PLA0230</B>: Detection of Human Beta-catenin by Immunohistochemistry. Sample: FFPE section of Human prostate carcinoma. Antibody: Affinity purified Rabbit Anti-Beta-catenin (<B>Cat. No. PLA0230</B>) used at a dilution of 1:200 (1 μg/mL). Detection: DAB staining.

Human Total beta-Catenin DuoSet IC ELISA - DYC1329-2 from R&D Systems

Category ELISA Kit
Prices $329.00, $649.00, $1,395.00
Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates)
Range 312.00 - 20,000 pg/mL

Human Total beta-Catenin DuoSet IC, 5 Plate - DYC1329-5 from R&D Systems

Category ELISA Kit

Human Total beta-Catenin Surveyor IC - SUV1329 from R&D Systems

Category ELISA Kit
Prices $529.00
Sizes 1 kit

Human/Mouse Total beta-Catenin Cell-Based ELISA - KCB1329 from R&D Systems

Category ELISA Kit
Prices $459.00
Sizes 1 kit

beta Catenin ELISA kit - 55R-IB09614 from Fitzgerald

Category ELISA Kit
Prices $805.00
Sizes 96 wells

Catenin Beta 1 (CTNNb1), Human, ELISA Kit - SEB021Hu from ARP American Research Products

Category ELISA Kit
Prices $685.00
Sizes 96 t
Sensitivity 6.4pg/mL
Range 15.6-1,000pg/mL

Catenin beta-1, CTNNB1, Human, ELISA Kit - E1021h from ARP American Research Products

Category ELISA Kit
Prices $476.00
Sizes 96 t
Range 0.312-20 ng/mL

Catenin beta-1, Human, ELISA Kit - CSB-E08963h from ARP American Research Products

Category ELISA Kit
Prices $550.00, $790.00, $791.00, $794.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 3.9 pg/ml
Range 15.6 pg/ml-1000 pg/ml
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