CTNNB1

Gene Symbol	CTNNB1
Entrez Gene	1499
Alt Symbol	CTNNB, MRD19, armadillo
Species	Human
Gene Type	protein-coding
Description	catenin (cadherin-associated protein), beta 1, 88kDa
Other Description	catenin beta-1
Swissprots	Q8NEW9 P35222 Q9H391 A8K1L7 Q8NI94
Accessions	AAD32267 AAL89457 AAR18817 ACD11099 ACD11101 AEW16366 CCH22596 EAW64625 EAW64626 EAW64627 EAW64628 P35222 AB062292 BAB93475 AB451264 BAG70078 AB451392 BAG70206 AK095242 AK289932 BAF82621 AK294778 BAG57905 AK296790 BAG59368 AK299954 BAG61781 AK314776 BC058926 AAH58926 BX648430 DA216720 EU446854 ABZ92383 U38440 X87838 CAA61107 Z19054 CAA79497 XM_005264886 XP_005264943 XM_006712983 XP_006713046 XM_006712984 XP_006713047 XM_006712985 XP_006713048 NM_001098209 NP_001091679 NM_001098210 NP_001091680 NM_001904 NP_001895
Function	Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:212
Subcellular Location	Cytoplasm. Nucleus {ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane {ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell
Tissue Specificity	Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). {ECO:0000269|PubMed:11703283, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17289029}.
Top Pathways	Proteoglycans in cancer, HTLV-I infection, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

beta Catenin peptide - ab116624 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human beta Catenin (phospho S33) peptide - ab73676 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human beta Catenin (phospho Y142) peptide - ab42714 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Human

Human beta Catenin (phospho Y142) peptide - ab100819 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human beta Catenin (phospho Y86) peptide - ab42713 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Human

Human beta Catenin full length protein - ab63175 from Abcam Category Protein Prices $373.00 Sizes 50 µg Source Baculovirus infected sf9 cells Species Human

Human beta Catenin full length protein - ab158230 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human beta Catenin peptide - ab42711 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Human

Human beta Catenin peptide - ab42712 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Human

Human beta Catenin peptide - ab16377 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human beta Catenin peptide - ab73677 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human beta Catenin protein fragment - ab158231 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CTNNB1 / Beta Catenin Antibody Blocking Peptide - LS-E10536 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CTNNB1 / Beta Catenin Antibody Blocking Peptide - LS-E10759 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CTNNB1 / Beta Catenin Antibody Blocking Peptide - LS-E10760 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human beta-Catenin Protein - H00001499-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

beta-Catenin Partial Recombinant Protein - H00001499-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CTNB1-Antibody-C-term-Blocking-peptide - BP11231b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CTNNB1-AntibodyC-term-Blocking-peptide - BP19562b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CTNNB1-N-term-Blocking-peptide - BP19561a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CTNNB1-AntibodyC-term-Blocking-peptide - BP19559b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Catenin beta-1 protein (OPCA00320) - OPCA00320 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human CTNNB1 protein - orb245021 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human CTNNB1 His GST tag protein - orb84529 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source Insect Species Human

CTNNB1 peptide - orb217157 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Rabbit, Zebrafish, Monkey, Drosophila, Sheep, Cat

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