Casp3

Gene Symbol Casp3
Entrez Gene 12367
Alt Symbol A830040C14Rik, AC-3, Apopain, CASP-3, CC3, CPP-32, CPP32, Caspase-3, Lice, SCA-1, Yama, mldy
Species Mouse
Gene Type protein-coding
Description caspase 3
Other Description SREBP cleavage activity 1|caspase 3, apoptosis related cysteine protease|caspase-3|cysteine protease CPP32|protein Yama
Swissprots O08668 Q8CHV5 Q9QWI4 P70677
Accessions AAC52768 EDL35577 EDL35578 EDL35579 EDL35580 EDL35581 EDL35582 P70677 AK014231 AK049043 AK080651 BAC37969 AK146226 BC021500 BC038825 AAH38825 D86352 BAA21727 U19522 AAC53196 U49929 AAC52764 U63720 AAD09504 Y13086 CAA73528 NM_001284409 NP_001271338 NM_009810 NP_033940
Function Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. {ECO:0000250}.
Subcellular Location Cytoplasm.
Tissue Specificity Highest expression in spleen, lung, liver, kidney and heart. Lower expression in brain, skeletal muscle and testis.
Top Pathways Toxoplasmosis, TNF signaling pathway, MicroRNAs in cancer, Non-alcoholic fatty liver disease (NAFLD), Proteoglycans in cancer

Anti-Sca-1 Antibody (clone CT-6A/6E, PE) - LS-C62604 from LifeSpan Bioscience

Prices $285.00, $950.00
Sizes 50 µg, 300 µg
Host Rat
Clonality Monoclonal
Clone CT-6A/6E

Anti-Sca-1 Antibody (clone CT-6A/6E) - LS-C62928 from LifeSpan Bioscience

Prices $335.00
Sizes 200 µg
Host Rat
Clonality Monoclonal
Clone CT-6A/6E

Sca-1/Ly6 Antibody - AF1226 from Novus Biologicals

Prices $99.00, $365.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Sca‑1/Ly6 was detected in immersion fixed mouse splenocytes using 10 µg/mL Goat Anti-Mouse Sca‑1/Ly6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1226) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Sca-1/Ly6 Antibody (177228) [Biotin] - BAM1226 from Novus Biologicals

Prices $389.00
Sizes 250 µg
Host Rat
Clonality Monoclonal
Clone 177228
Sca-1/Ly6 was detected in perfusion fixed frozen sections of mouse kidney using Mouse Sca-1/Ly6 Biotinylated Monoclonal Antibody (Catalog # BAM1226) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Sca-1/Ly6 Antibody [Biotin] - BAF1226 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Sca‑1/Ly6 was detected in immersion fixed mouse splenocytes using 10 µg/mL Goat Anti-Mouse Sca‑1/Ly6 Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF1226) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Streptavidin (red; Catalog # NL999) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Sca-1/Ly6 Antibody (177228) [Allophycocyanin] - FAB1226A from Novus Biologicals

Prices $179.00
Sizes 25 tests
Host Rat
Clonality Monoclonal
Clone 177228
Mouse splenocytes were stained with Rat Anti-Mouse Sca-1/Ly6 APC-conjugated Monoclonal Antibody (Catalog # FAB1226A, filled histogram) or isotype control antibody (Catalog # IC006A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Sca-1/Ly6 Antibody (177228) [Alexa Fluor 700] - FAB1226N from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rat
Clonality Monoclonal
Clone 177228
Mouse splenocytes gated on hematopoietic lineage negative cells were stained with Rat Anti-Mouse CD117/c-kit PE-conjugated Monoclonal Antibody (Catalog # FAB1356P) and either (A) Rat Anti-Mouse Sca-1/Ly6 Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # FAB1226N) or (B) Rat IgG2A Alexa Fluor 700 Isotype Control (Catalog # IC006N). View our protocol for Staining Membrane-associated Proteins.

Sca-1/Ly6 Antibody (177228) [Alexa Fluor 488] - FAB1226G from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rat
Clonality Monoclonal
Clone 177228
Mouse splenocytes were stained with Rat Anti-Mouse Sca-1/Ly6 Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB1226G, filled histogram) or isotype control antibody (Catalog # IC006G, open histogram). View our protocol for Staining Membrane-associated Proteins.

Sca-1/Ly6 Antibody (177228) [Phycoerythrin] - FAB1226P from Novus Biologicals

Prices $299.00
Sizes 100 tests
Host Rat
Clonality Monoclonal
Clone 177228
Mouse splenocytes gated on hematopoietic lineage negative cells were stained with Rat Anti-Mouse CD117/c-kit APC-conjugated Monoclonal Antibody (Catalog # FAB1356A) and either (A) Rat Anti-Mouse Sca-1/Ly6 PE-conjugated Monoclonal Antibody (Catalog # FAB1226P) or (B) Rat IgG2A Phycoerythrin Isotype Control (Catalog # IC006P). View our protocol for Staining Membrane-associated Proteins.

Casp3 Antibody - middle region (ARP60988_P050) - ARP60988_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Phospho-mouse-CASP3S26-Antibody - AP3778d from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Dot blot analysis of Phospho-mouse CASP3-S26 Antibody Phospho-specific Pab (Cat. #AP3778d) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

Phospho-mouse-CASP3S12-Antibody - AP3778b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Dot blot analysis of Phospho-mouse CASP3-S12 Antibody Phospho-specific Pab (Cat. #AP3778b) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

CASP3 Antibody (Phospho-Ser12) (OAAB16261) - OAAB16261 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

CASP3 Antibody (Phospho-Ser26) (OAAB16263) - OAAB16263 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Rabbit anti-human Caspase-3 (OACA01231) - OACA01231 from Aviva Systems Biology

Prices $270.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Rabbit anti-human Caspase-3 (OACA01232) - OACA01232 from Aviva Systems Biology

Prices $270.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Rabbit anti-human Caspase-3 (OACA01233) - OACA01233 from Aviva Systems Biology

Prices $270.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Rabbit anti-human Caspase-3 (OACA01234) - OACA01234 from Aviva Systems Biology

Prices $270.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Caspase 3 antibody - 70R-33463 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Caspase 3 antibody - 70R-31076 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

CASP3 antibody - 70R-31133 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Caspase-3 Antibody (OAED00052) - OAED00052 from Aviva Systems Biology

Prices $180.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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