Gene Symbol | Casp3 |
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Entrez Gene | 12367 |
Alt Symbol | A830040C14Rik, AC-3, Apopain, CASP-3, CC3, CPP-32, CPP32, Caspase-3, Lice, SCA-1, Yama, mldy |
Species | Mouse |
Gene Type | protein-coding |
Description | caspase 3 |
Other Description | SREBP cleavage activity 1|caspase 3, apoptosis related cysteine protease|caspase-3|cysteine protease CPP32|protein Yama |
Swissprots | O08668 Q8CHV5 Q9QWI4 P70677 |
Accessions | AAC52768 EDL35577 EDL35578 EDL35579 EDL35580 EDL35581 EDL35582 P70677 AK014231 AK049043 AK080651 BAC37969 AK146226 BC021500 BC038825 AAH38825 D86352 BAA21727 U19522 AAC53196 U49929 AAC52764 U63720 AAD09504 Y13086 CAA73528 NM_001284409 NP_001271338 NM_009810 NP_033940 |
Function | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. {ECO:0000250}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Highest expression in spleen, lung, liver, kidney and heart. Lower expression in brain, skeletal muscle and testis. |
Top Pathways | Toxoplasmosis, TNF signaling pathway, MicroRNAs in cancer, Non-alcoholic fatty liver disease (NAFLD), Proteoglycans in cancer |
SignalSilence ® Caspase-3 siRNA II (Mouse Specific) - 6501 from Cell Signaling Technology
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SignalSilence ® Caspase-3 siRNA I (Mouse Specific) - 6488 from Cell Signaling Technology
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caspase-3 CRISPR/Cas9 KO Plasmid (m) - sc-419466 from Santa Cruz Biotechnology
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caspase-3 HDR Plasmid (m) - sc-419466-HDR from Santa Cruz Biotechnology
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caspase-3 Double Nickase Plasmid (m) - sc-419466-NIC from Santa Cruz Biotechnology
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caspase-3 Double Nickase Plasmid (m2) - sc-419466-NIC-2 from Santa Cruz Biotechnology
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caspase-3 CRISPR Activation Plasmid (m) - sc-419466-ACT from Santa Cruz Biotechnology
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caspase-3 CRISPR Activation Plasmid (m2) - sc-419466-ACT-2 from Santa Cruz Biotechnology
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caspase-3 Lentiviral Activation Particles (m) - sc-419466-LAC from Santa Cruz Biotechnology
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caspase-3 Lentiviral Activation Particles (m2) - sc-419466-LAC-2 from Santa Cruz Biotechnology
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caspase-3 siRNA (m) - sc-29927 from Santa Cruz Biotechnology
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caspase-3 shRNA Plasmid (m) - sc-29927-SH from Santa Cruz Biotechnology
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caspase-3 shRNA (m) Lentiviral Particles - sc-29927-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN28016 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28016 from Sigma-Aldrich
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CASP3 siRNA (Mouse) - CRM0509 from Cohesion Biosciences
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CASP3 - MBS8230523 from MyBioSource
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shRNA set against Mouse CASP3 (NM_009810.2) - SHH254977 from Creative biogene
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shRNA set against Mouse Casp3(NM_009810.2) - SHG142377 from Creative biogene
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Mouse CASP3 siRNA - orb279985 from Biorbyt
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CASP3 shRNA Plasmid (Mouse) - CHM0509 from Cohesion Biosciences
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CASP3 miRNA 3'UTR clone - MiUTR1M-02542 from Creative biogene
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