PPAP2A

Gene Symbol PPAP2A
Entrez Gene 8611
Alt Symbol LLP1a, LPP1, PAP-2a, PAP2
Species Human
Gene Type protein-coding
Description phosphatidic acid phosphatase type 2A
Other Description lipid phosphate phosphohydrolase 1|lipid phosphate phosphohydrolase 1a|phosphatidate phosphohydrolase type 2a|phosphatidic acid phosphatase 2a|phosphatidic acid phosphohydrolase type 2a|type-2 phosphatidic acid phosphatase alpha
Swissprots Q17RZ4 O60457 O14494 O60463 G3XA95 B7ZKN8
Accessions CCF77023 CCF77024 EAW54920 EAW54921 EAW54922 EAW54923 O14494 AB000888 BAA22593 AF014402 AAC16032 AF014403 AAC16033 AF017116 AAC32041 AK124204 BC008787 BC039847 AAH39847 BC117133 AAI17134 BC143281 AAI43282 BC168254 BI761588 BQ019387 CN338068 HQ448545 ADQ33024 HY063640 XM_006714724 XP_006714787 NM_003711 NP_003702 NM_176895 NP_795714 NR_103485
Function Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. {ECO:0000269|PubMed:12909631}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas.
Top Pathways Fc gamma R-mediated phagocytosis, Fat digestion and absorption, Choline metabolism in cancer, Ether lipid metabolism, Glycerolipid metabolism

Human-PPAP2A-cDNA-Clone - DC07303 from Abgent, a WuXi AppTec company

Prices $383.40
Sizes 10 µg
Species Human
Accession BC039847

PPAP2A - MBS1272323 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC039847

Human PPAP2A ORF Clone(NM_003711.2) - CDCR286307 from Creative biogene

Species Human

human PPAP2A ORF clone (NM_176895.1) - CDCH066354 from Creative biogene

Species Human

Human PPAP2A ORF Clone (BC039847) - CDCS411421 from Creative biogene

Species Human
Accession G3XA95

Human PPAP2A cDNA Clone(NM_176895.1) - CDFG011307 from Creative biogene

Species Human

Human PPAP2A cDNA Clone(NM_176895.1) - CDFG011308 from Creative biogene

Species Human

Human PPAP2A cDNA Clone(NM_003711.2) - CDFH014793 from Creative biogene

Species Human
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