PPAP2A

Gene Symbol PPAP2A
Entrez Gene 8611
Alt Symbol LLP1a, LPP1, PAP-2a, PAP2
Species Human
Gene Type protein-coding
Description phosphatidic acid phosphatase type 2A
Other Description lipid phosphate phosphohydrolase 1|lipid phosphate phosphohydrolase 1a|phosphatidate phosphohydrolase type 2a|phosphatidic acid phosphatase 2a|phosphatidic acid phosphohydrolase type 2a|type-2 phosphatidic acid phosphatase alpha
Swissprots Q17RZ4 O60457 O14494 O60463 G3XA95 B7ZKN8
Accessions CCF77023 CCF77024 EAW54920 EAW54921 EAW54922 EAW54923 O14494 AB000888 BAA22593 AF014402 AAC16032 AF014403 AAC16033 AF017116 AAC32041 AK124204 BC008787 BC039847 AAH39847 BC117133 AAI17134 BC143281 AAI43282 BC168254 BI761588 BQ019387 CN338068 HQ448545 ADQ33024 HY063640 XM_006714724 XP_006714787 NM_003711 NP_003702 NM_176895 NP_795714 NR_103485
Function Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. {ECO:0000269|PubMed:12909631}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas.
Top Pathways Fc gamma R-mediated phagocytosis, Fat digestion and absorption, Choline metabolism in cancer, Ether lipid metabolism, Glycerolipid metabolism

PAP-2a (D-16) - sc-51390 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PAP-2a (D-16): sc-51390. Western blot analysis of PAP-2a expression in PANC-1 whole cell lysate.

PAP-2a (H-78) - sc-292531 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PAP-2a (R-16) - sc-51394 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PAP-2a (R-16): sc-51394. Western blot analysis of PAP-2a expression in non-transfected: sc-117512 (A) and human PAP-2a transfected: sc-115817 (B) 293T whole cell lysates.

PAP-2a (G-16) - sc-51392 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PAP-2a (A-22) - sc-133882 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
PAP-2a (A-22): sc-133882. Western blot analysis of PAP-2a expression in Hep G2 whole cell lysate.

Anti-PPAP2A antibody - ab198280 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PPAP2A antibody (ab198280) at 1/650 dilution + Human liver cancer tissue lysate at 30 µg

Anti-PPAP2A antibody - ab58745 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PPAP2A antibody (ab58745) at 5 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/ 50,000 - 1/100,000 dilution.

Anti-PPAP2A antibody - ab169621 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PPAP2A antibody (ab169621) at 1 µg/mlLane 1 : PPAP2A transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-PPAP2A antibody [1H4] - ab170151 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H4
Immunohistochemical analysis of paraffin-embedded Human lymph node tissue labeling PPAP2A with ab170151 at 1/150 dilution.

Anti-PAP2a / PPAP2A Antibody (clone 1H4) - LS-C340621 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H4
IHC of paraffin-embedded Human liver tissue using anti-PPAP2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-PAP2a / PPAP2A Antibody - LS-C140506 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PAP2a / PPAP2A Antibody (aa35-84) - LS-C117161 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PPAP2A antibody LS-C117161 Western blot of HepG2 cell lysate.

Anti-PAP2a / PPAP2A Antibody (aa136-185) - LS-C40365 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
PPAP2A antibody LS-C40365 Western blot of Jurkat lysate.

Anti-PAP2a / PPAP2A Antibody (aa31-80) - LS-C31901 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
PPAP2A antibody LS-C31901 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

PPAP2A Antibody - NBP1-59025 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PPAP2A Antibody [NBP1-59025] - Jurkat cell lysate, Antibody Titration: 2.5ug/ml

PPAP2A Antibody - NBP2-32057 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: PPAP2A Antibody [NBP2-32057] - Staining of human prostate shows strong membranous and cytoplasmic positivity in glandular cells.

PPAP2A Antibody - NBP1-59011 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PPAP2A Antibody [NBP1-59011] - HepG2 cell lysate, Antibody Titration: 5.0ug/ml

PAP2 Antibody - NBP1-91086 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: PAP2 Antibody [NBP1-91086] - Staining of human cell line U-2 OS shows positivity in plasma membrane, cytoplasm and centrosome.

PAP2 Antibody - NBP1-70670 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PPAP2A Antibody - H00008611-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PPAP2A Antibody [H00008611-D01P] - Analysis of PPAP2A expression in human pancreas.

PPAP2A Antibody - H00008611-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: PPAP2A Antibody [H00008611-B01P] - Analysis of PPAP2A expression in human kidney.

PPAP2A Polyclonal Antibody - bs-5423R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PPAP2A (AB2) antibody produced in rabbit - AV42721 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PPAP2A (ab2): <B>Cat. No. AV42721</B>: Immunohistochemistry of PPAP2A in Human Kidney tissue with PPAP2A antibody at 4-8 μg/mL.

Anti-PPAP2A (AB1) antibody produced in rabbit - AV42146 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PPAP2A (ab1): <B>Cat. No. AV42146</B>: Immunohistochemistry of PPAP2A in Mouse primary tissue, focusing in pLN tissue with PPAP2A antibody at 1 μg/mL. Green = CD31. Red = B220. Blue = LPP1 staining.

Anti-PPAP2A antibody produced in rabbit - HPA047815 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PPAP2A: <B>Cat. No. HPA047815</B>: Immunohistochemical staining of Human prostate shows strong membranous and cytoplasmic positivity in glandular cells.
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