| Gene Symbol |
PLA2R1
|
| Entrez Gene |
22925
|
| Alt Symbol |
CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase A2 receptor 1, 180kDa
|
| Other Description |
180 kDa secretory phospholipase A2 receptor|C-type lectin domain family 13 member C|M-type receptor|phospholipase A2 receptor 1, 180kD|secretory phospholipase A2 receptor
|
| Swissprots |
D3DPB1 Q13019 Q15095 Q53R45 B2RTU9 Q53RR7 Q13018
|
| Accessions |
AAY24052 AAY24190 CCQ43399 EAX11391 EAX11392 EAX11393 Q13018 AI672072 AL598405 BC140823 AAI40824 BC144631 AAI44632 BF725498 BF805380 BP351340 BQ025507 BQ637466 BX485732 D30780 BAA06444 U17033 AAA70110 U17034 AAC50163 W15508 XM_005246392 XP_005246449 XM_005246393 XP_005246450 XM_005246395 XP_005246452 XM_006712369 XP_006712432 XM_011510820 XP_011509122 XM_011510821 XP_011509123 XR_922892 NM_001007267 NP_001007268 NM_001195641 NP_001182570 NM_007366 NP_031392
|
| Function |
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPL
|
| Subcellular Location |
Isoform 2: Secreted {ECO:0000305}.
|
| Tissue Specificity |
Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level. {ECO:0000269|PubMed:15611272, ECO:0000269|PubMed:7721806, ECO:0000269|PubMed:7925459, ECO:0000269|PubMed:9481783}.
|
| Top Pathways |
Phagosome, Tuberculosis
|