PLA2R1

Gene Symbol PLA2R1
Entrez Gene 22925
Alt Symbol CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R
Species Human
Gene Type protein-coding
Description phospholipase A2 receptor 1, 180kDa
Other Description 180 kDa secretory phospholipase A2 receptor|C-type lectin domain family 13 member C|M-type receptor|phospholipase A2 receptor 1, 180kD|secretory phospholipase A2 receptor
Swissprots D3DPB1 Q13019 Q15095 Q53R45 B2RTU9 Q53RR7 Q13018
Accessions AAY24052 AAY24190 CCQ43399 EAX11391 EAX11392 EAX11393 Q13018 AI672072 AL598405 BC140823 AAI40824 BC144631 AAI44632 BF725498 BF805380 BP351340 BQ025507 BQ637466 BX485732 D30780 BAA06444 U17033 AAA70110 U17034 AAC50163 W15508 XM_005246392 XP_005246449 XM_005246393 XP_005246450 XM_005246395 XP_005246452 XM_006712369 XP_006712432 XM_011510820 XP_011509122 XM_011510821 XP_011509123 XR_922892 NM_001007267 NP_001007268 NM_001195641 NP_001182570 NM_007366 NP_031392
Function Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPL
Subcellular Location Isoform 2: Secreted {ECO:0000305}.
Tissue Specificity Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level. {ECO:0000269|PubMed:15611272, ECO:0000269|PubMed:7721806, ECO:0000269|PubMed:7925459, ECO:0000269|PubMed:9481783}.
Top Pathways Phagosome, Tuberculosis

PLA2R CRISPR/Cas9 KO Plasmid (h) - sc-411636 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLA2R HDR Plasmid (h) - sc-411636-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLA2R Double Nickase Plasmid (h) - sc-411636-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLA2R Double Nickase Plasmid (h2) - sc-411636-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLA2R CRISPR Activation Plasmid (h) - sc-411636-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLA2R CRISPR Activation Plasmid (h2) - sc-411636-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLA2R Lentiviral Activation Particles (h) - sc-411636-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLA2R Lentiviral Activation Particles (h2) - sc-411636-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLA2R siRNA (h) - sc-94746 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLA2R shRNA Plasmid (h) - sc-94746-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLA2R shRNA (h) Lentiviral Particles - sc-94746-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLA2R1 RNAi - H00022925-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

PLA2R1 RNAi - H00022925-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU022561 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16903 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16903 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07678 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07678

PLA2R1 siRNA (Human) - CRH7876 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PLA2R1 (NM_007366.4) - SHH376916 from Creative biogene

Category siRNA
Species Reactivities Human

Human PLA2R1 siRNA - orb268378 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PLA2R1 shRNA Plasmid (Human) - CHH7876 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PLA2R1 miRNA 3'UTR clone - MiUTR3H-07232 from Creative biogene

Species Reactivities Human

PLA2R1 miRNA 3'UTR clone - MiUTR3H-07233 from Creative biogene

Species Reactivities Human
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