| Gene Symbol |
ATP5A1
|
| Entrez Gene |
100157880
|
| Alt Symbol |
ATP5A2
|
| Species |
Pig
|
| Gene Type |
protein-coding
|
| Description |
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
|
| Other Description |
ATP synthase subunit alpha heart isoform, mitochondrial|ATP synthase subunit alpha liver isoform, mitochondrial|ATP synthase subunit alpha, mitochondrial|cardiac muscle ATP synthase H+ transporting mitochondrial F1 complex alpha subunit 1
|
| Swissprots |
Q29596 B2ZF46 P80021
|
| Accessions |
P80021 AK232528 AK236714 AK238748 AK239102 AK397056 AY609645 EU650784 ACD02421 NM_001185142 NP_001172071
|
| Function |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Note=Colocalizes with HRG on the cell surface of T-cells. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart (at protein level). Detected in liver.
|
| Top Pathways |
Alzheimer's disease, Huntington's disease, Oxidative phosphorylation
|