ATR

Gene Symbol	ATR
Entrez Gene	545
Alt Symbol	FCTCS, FRP1, MEC1, SCKL, SCKL1
Species	Human
Gene Type	protein-coding
Description	ATR serine/threonine kinase
Other Description	FRAP-related protein-1|MEC1, mitosis entry checkpoint 1, homolog|ataxia telangiectasia and Rad3-related protein|serine/threonine-protein kinase ATR
Swissprots	Q13535 Q9BXK4 Q59HB2 Q7KYL3 Q93051
Accessions	AAK26749 CAA03590 EAW78969 EAW78970 Q13535 AB208847 BAD92084 AK307402 BC172404 AAI72404 BE859077 DC346860 U49844 AAC50405 U76308 AAC50929 Y09077 CAA70298 XM_011512924 XP_011511226 XM_011512925 XP_011511227 XM_011512926 XP_011511228 XM_011512927 XP_011511229 XR_924147 XR_924148 XR_924149 NM_001184 NP_001175
Function	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. {ECO:0000269|PubMed:10597277, ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164, ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805, ECO:0000269|PubMed:127919
Subcellular Location	Nucleus {ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14871897, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:8843195}. Nucleus, PML body {ECO:0000250}. Chromosome {ECO:0000250}. Note=Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.
Tissue Specificity	Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary. {ECO:0000269|PubMed:11470508, ECO:0000269|PubMed:8610130, ECO:0000269|PubMed:8843195}.
Top Pathways	Cell cycle, p53 signaling pathway, HTLV-I infection, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ATR protein fragment - ab125979 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

Recombinant Human ATR Protein - H00000545-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ATR Blocking Peptide - NBP1-77232PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TEM8/ANTXR1 Blocking Peptide - NBP1-77233PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TEM8 blocking peptide - GTX15724-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Rat, Bovine

ATR / FRP1 - H00000545-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ATR / FRP1 - H00000545-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MMAB 33-250aa - CMB-510 from Reagent Proteins Category Protein Prices $469.00, $889.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

Recombinant Ataxia Telangiectasia And Rad3 Related Protein (ATR) - RPK284Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Secreted Frizzled Related Protein 1 (SFRP1) - RPF880Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Ataxia Telangiectasia And Rad3 Related Protein (ATR) - RPK284Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Serine/threonine-protein kinase ATR(ATR) ,partial - CSB-YP622666HU CSB-EP622666HU CSB-BP622666HU CSB-MP622666HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Human ATR protein fragment - ab204140 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

ATR (201-340) - sc-4476 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

ATR Protein - NBP1-83424PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ATR-Antibody-Center-Blocking-Peptide - BP8047c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATR-Antibody-C-term-Blocking-Peptide - BP8047b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ATR Peptide, Human - M34GP01210H from Creative Peptides Category Peptide Source Synthetic. Species Human

ATR Recombinant Protein (OPCD01548) - OPCD01548 from Aviva Systems Biology Category Protein Source E.coli Species Human

Serine/threonine-protein kinase ATR (ATR), partial, Recombinant Protein - MBS1424667 from MyBioSource Category Protein Prices $730.00, $855.00, $985.00, $990.00, $1,075.00, $1,145.00, $1,235.00, $1,255.00, $1,300.00, $1,530.00, $1,805.00, $1,875.00, $1,970.00, $2,400.00 Sizes 50 µg (E-Coli), 50 µg (Yeast), 200 µg (E-Coli), 50 µg (Baculovirus), 500 µg (E-Coli), 200 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 500 µg (Yeast), 1 mg (E-Coli), 500 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human ATR Protein, GST-tagged - ATR-4932H from Creative Biomart Category Protein Source Insect cells Species Human

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