NOTCH2

Gene Symbol NOTCH2
Entrez Gene 4853
Alt Symbol AGS2, HJCYS, hN2
Species Human
Gene Type protein-coding
Description notch 2
Other Description Notch homolog 2|neurogenic locus notch homolog protein 2
Swissprots Q5T3X7 Q9H240 Q99734 Q04721
Accessions AAB17664 CAH70182 EAW56718 EAW56719 Q04721 AF308601 AAA36377 AF315356 AAG37073 AK027869 BAB55419 AK307843 AL049386 AL133036 CAB61366 BC071562 AAH71562 BG718124 DB290699 GQ231534 ADB12482 U77493 AAB19224 XM_005270901 XP_005270958 XM_011541519 XP_011539821 XM_011541520 XP_011539822 NM_001200001 NP_001186930 NM_024408 NP_077719
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. {ECO:0000250, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo. {ECO:0000269|PubMed:21378985}.
Top Pathways Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

Notch2 (D67C8) XP ® Rabbit mAb - 4530 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D67C8
Western blot analysis of extracts from various cell lines using Notch2 (D67C8) XP ® Rabbit mAb. The full-length (FL) Notch2 protein and the transmembrane/intracellular region (NTM) are indicated.

Notch2 (D76A6) XP ® Rabbit mAb - 5732 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D76A6
Western blot analysis of extracts from 293 and SK-MEL-5 cells using Notch2 (D76A6) XP ® Rabbit mAb. The full-length (FL) Notch2 protein and the transmembrane/intracellular region (NTM) are indicated.

Notch2 (8A1) Rabbit mAb - 2420 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 8A1
Western blot analysis of extracts from SNB19 and 293 cells, untreated or stably expressing human Notch2, using Notch2 (8A1) Rabbit mAb. The full-length (FL) and the extracellular domain (EC) of Notch2 are indicated.

Notch 2 (25-255) - sc-5545 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Notch 2 (25-255): sc-5545. Immunofluorescence staining of normal mouse intestine frozen section showing membrane staining.

Notch 2 (E-14) - sc-32344 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Notch 2 (L-12) - sc-32346 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Notch 2 (L-12): sc-32346. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing membrane and cytoplasmic staining of glandular cells.

Anti-Notch 2 intracellular domain antibody - ab8927 from Abcam

Prices $378.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Notch 2 intracellular domain antibody - Cleaved - Asp1733 - ab52302 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Notch 2 intracellular domain antibody - Cleaved - Asp1733 (ab52302) at 1/300 dilutionLane 1 : 293 cell extract treated with TNF-alpha (20ng/ml, 30mins)Lane 2 : 293 cell extract treated with TNF-alpha (20ng/ml, 30mins) with immunising peptideObserved band size : 110 kDa (why is the actual band size different from the predicted?)

Anti-Notch2 antibody - ab8926 from Abcam

Prices $384.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Staining of Human corneal epithelial cells with anti-Notch2 (ab8926, 1/100). The Notch2 (green staining) is localised in the cytoplasm. The nucleus is stained with Bis benzimide (1/500)

Anti-Notch2 antibody - ab118824 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab118824, at a 1/500 dilution, staining Notch2 in formalin fixed, paraffin embedded Human kidney tissue followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Notch2 antibody - ab137665 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Notch2 antibody (ab137665) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-Notch2 antibody - ab99404 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab99404, at a 1/250 dilution, staining Human Notch2 in breast carcinoma tissue by Immunohistochemistry. Formalin/PFA-fixed paraffin-embedded tissue using DAB detection.

Anti-Notch2 antibody [MM084439M21] - ab201649 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM084439M21

Anti-Notch2 antibody [MM0845-48N11] - ab201616 from Abcam

Prices $359.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone MM0845-48N11

Anti-NOTCH2 / NOTCH-2 Antibody (aa2457-2471) - LS-C9340 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NOTCH2 Antibody (aa2396-2409) - LS-C9341 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NOTCH2 Antibody (aa2063-2413) - LS-C37773 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-NOTCH2 / NOTCH-2 Antibody (aa2396-2409) - LS-C73702 from LifeSpan Bioscience

Prices $575.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NOTCH2 Antibody (aa2399-2412) - LS-C55184 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-NOTCH2 Antibody (C-Terminus) - LS-C83738 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NOTCH2 Antibody (clone 8A1) - LS-C73704 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone 8A1

Anti-NOTCH2 / NOTCH-2 Antibody (aa2396-2409) - LS-C124295 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-NOTCH2 Antibody (N-Terminus) - LS-C124296 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NOTCH2 / NOTCH-2 Antibody (aa26-492, PE) - LS-C126055 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Goat
Clonality Polyclonal

Anti-NOTCH2 Antibody - LS-C126054 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
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