CXCL8
| Gene Symbol | CXCL8 |
|---|---|
| Entrez Gene | 3576 |
| Alt Symbol | GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-X-C motif) ligand 8 |
| Other Description | T-cell chemotactic factor|alveolar macrophage chemotactic factor I|beta endothelial cell-derived neutrophil activating peptide|beta-thromboglobulin-like protein|emoctakin|granulocyte chemotactic protein 1|interleukin 8|interleukin-8|lung giant cell carcinoma-derived chemotactic protein|lymphocyte derived neutrophil activating peptide|monocyte-derived neutrophil chemotactic factor|monocyte-derived neutrophil-activating peptide|neutrophil-activating peptide 1|small inducible cytokine subfamily B, member 8|tumor necrosis factor-induced gene 1 |
| Swissprots | Q6LAE6 P10145 Q9C077 Q6FGF6 Q9UCR9 Q9UCR8 Q9UCE1 B2R4L8 Q96RG6 Q9UCS0 |
| Accessions | AAA59158 AAK60276 BAA03245 CBK51144 CBX54344 EAX05687 EAX05688 EAX05689 P10145 AJ227913 AK131067 AK311874 BAG34815 BC013615 AAH13615 BG497712 BT007067 AAP35730 CR542151 CAG46948 DQ890564 ABM92181 DQ893727 ABM84653 M17017 AAA35611 M23344 AAA74722 M26383 AAA36323 Y00787 CAA68742 Z11686 CAA77745 NM_000584 NP_000575 |
| Function | IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. {ECO:0000269|PubMed:11978786, ECO:0000269|PubMed:2145175, ECO:0000269|PubMed:2212672}. |
| Subcellular Location | Secreted. |
| Top Pathways | Malaria, Legionellosis, Salmonella infection, Influenza A, Non-alcoholic fatty liver disease (NAFLD) |
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