DOK1

Gene Symbol DOK1
Entrez Gene 1796
Alt Symbol P62DOK
Species Human
Gene Type protein-coding
Description docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Other Description Downstream of tyrosine kinase 1|docking protein 1|docking protein 1 (downstream of tyrosine kinase 1)|p62(dok)|pp62
Swissprots Q53TY2 O43204 Q99704 Q9UHG6
Accessions AAX93224 EAW99612 EAW99613 EAW99614 Q99704 AF035299 AAB88182 AF180527 AAF19167 AK055944 BAG51595 AK127127 BAG54440 AK127656 BAG54544 AK222883 BAD96603 AK296154 BAG58893 AK300097 BAG61898 AK314678 BC111055 AAI11056 BC114440 AAI14441 BC114497 AAI14498 BQ575925 DA382785 DA599419 U70987 AAC51127 XM_011532669 XP_011530971 XM_011532670 XP_011530972 NM_001197260 NP_001184189 NM_001381 NP_001372
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}.
Subcellular Location Isoform 1: Cytoplasm. Nucleus.
Tissue Specificity Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. {ECO:0000269|PubMed:12595900}.
Top Pathways Measles

Dok-1 CRISPR/Cas9 KO Plasmid (h) - sc-401398 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-1 HDR Plasmid (h) - sc-401398-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-1 Double Nickase Plasmid (h) - sc-401398-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-1 Double Nickase Plasmid (h2) - sc-401398-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-1 CRISPR Activation Plasmid (h) - sc-401398-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-1 CRISPR Activation Plasmid (h2) - sc-401398-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-1 Lentiviral Activation Particles (h) - sc-401398-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-1 Lentiviral Activation Particles (h2) - sc-401398-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dok-1 siRNA (h) - sc-35210 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dok-1 shRNA Plasmid (h) - sc-35210-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dok-1 shRNA (h) Lentiviral Particles - sc-35210-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU157461 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7427 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7427 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03850 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03850

DOK1 siRNA (Human) - CRH1249 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DOK1 - MBS8211946 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DOK1 (NM_001381.3) - SHH280269 from Creative biogene

Category siRNA
Species Reactivities Human

Human DOK1 siRNA - orb261751 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DOK1 shRNA Plasmid (Human) - CHH1249 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DOK1 miRNA 3'UTR clone - MiUTR3H-05416 from Creative biogene

Species Reactivities Human
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