| Gene Symbol |
IL4R
|
| Entrez Gene |
3566
|
| Alt Symbol |
CD124, IL-4RA, IL4RA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 4 receptor
|
| Other Description |
IL-4 receptor subunit alpha|IL4R nirs variant 1|interleukin-4 receptor alpha chain|interleukin-4 receptor subunit alpha
|
| Swissprots |
Q9H188 Q9H187 Q96P01 B9EKU8 H3BSY5 Q9H183 Q9H186 P24394 Q9H185 B4E076 Q9H184 Q9H181 Q9H182
|
| Accessions |
AAC23495 AAL12163 CAC20445 CAC20446 CAC20447 CAC20448 CAC20449 CAC20450 CAC20451 CAC20452 CAJ01243 EAW55750 P24394 AA838318 AB102798 BAD89389 AK223591 BAD97311 AK303255 BAG64338 AK314863 BAG37378 BC110343 BC136365 AAI36366 BC151131 AAI51132 BX479288 DA492909 EF173858 ABM53131 X52425 CAA36672 XM_005255308 XP_005255365 XM_006721043 XP_006721106 XM_011545825 XP_011544127 XM_011545826 XP_011544128 XM_011545827 XP_011544129 XM_011545828 XP_011544130 XM_011545829 XP_011544131 XM_011545830 XP_011544132 XM_011545831 XP_011544133 XM_011545832 XP_011544134 XM_011545833 XP_011544135 XM_011545834 XP_011544136 NM_000418 NP_000409 NM_001257406 NP_001244335 NM_001257407 NP_001244336 NM_001257997 NP_001244926 NM_001008699
|
| Function |
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269|PubMed:8124718}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are highly expressed in activated T-cells.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, PI3K-Akt signaling pathway, Inflammatory bowel disease (IBD)
|