IL4R

Gene Symbol	IL4R
Entrez Gene	3566
Alt Symbol	CD124, IL-4RA, IL4RA
Species	Human
Gene Type	protein-coding
Description	interleukin 4 receptor
Other Description	IL-4 receptor subunit alpha|IL4R nirs variant 1|interleukin-4 receptor alpha chain|interleukin-4 receptor subunit alpha
Swissprots	Q9H188 Q9H187 Q96P01 B9EKU8 H3BSY5 Q9H183 Q9H186 P24394 Q9H185 B4E076 Q9H184 Q9H181 Q9H182
Accessions	AAC23495 AAL12163 CAC20445 CAC20446 CAC20447 CAC20448 CAC20449 CAC20450 CAC20451 CAC20452 CAJ01243 EAW55750 P24394 AA838318 AB102798 BAD89389 AK223591 BAD97311 AK303255 BAG64338 AK314863 BAG37378 BC110343 BC136365 AAI36366 BC151131 AAI51132 BX479288 DA492909 EF173858 ABM53131 X52425 CAA36672 XM_005255308 XP_005255365 XM_006721043 XP_006721106 XM_011545825 XP_011544127 XM_011545826 XP_011544128 XM_011545827 XP_011544129 XM_011545828 XP_011544130 XM_011545829 XP_011544131 XM_011545830 XP_011544132 XM_011545831 XP_011544133 XM_011545832 XP_011544134 XM_011545833 XP_011544135 XM_011545834 XP_011544136 NM_000418 NP_000409 NM_001257406 NP_001244335 NM_001257407 NP_001244336 NM_001257997 NP_001244926 NM_001008699
Function	Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269|PubMed:8124718}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Isoform 1 and isoform 2 are highly expressed in activated T-cells.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, PI3K-Akt signaling pathway, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IL4R protein fragment - ab167726 from Abcam Category Protein Prices $352.00 Sizes 50 µg Source HEK 293 cells Species Human

IL4RA protein (Fc Chimera) - ab83756 from Abcam Category Protein Prices $315.00 Sizes 25 µg Source HEK 293 cells Species Human

Human IL4 Receptor alpha protein fragment - ab158758 from Abcam Category Protein Source Wheat germ Species Human

IL4R / CD124 Antibody Blocking Peptide - LS-E22228 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IL-4 R alpha Protein - H00003566-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human IL-4 R alpha Protein - H00003566-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

IL-4 R alpha Recombinant Protein - P3682 from Novus Biologicals Category Protein Prices $689.00 Sizes 10 µg Species Human

Soluble IL-4 alpha Recombinant Protein (Active) - GTX48185-PRO from GeneTex Category Protein Prices $299.00 Sizes 15 μg Species Human

Recombinant Human IL-4 R alpha Fc Chimera, CF - 604-4R-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human IL-4 R alpha - 230-4R-025 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Gly24-His232

Recombinant Human IL-4 R alpha, CF - 230-4R-025/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Gly24-His232

Recombinant Mouse IL-4 R alpha Fc Chimera, CF - 530-MR-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human IL-4 R alpha, CF - 230-4RB-025 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (stably transfected)-derived, Met1-His232

Recombinant Human IL-4 R alpha Fc Chimera, CF - 7700-4R-050 from R&D Systems Category Protein Source Human embryonic kidney cell, HEK293-derived

Human CD124 His tag protein - orb83267 from Biorbyt Category Protein Prices $570.00, $859.00 Sizes 50 μg, 100 μg Source Human Species Human

CD124 / IL4R - PA233 from Acris Antibodies Category Protein Prices $135.00 Sizes 3 µg Source HEK293 cells Species Human

CD124 / IL4R - PA233X from Acris Antibodies Category Protein Prices $235.00 Sizes 15 µg Source HEK293 cells Species Human

CD124 / IL4R - H00003566-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD124 / IL4R - H00003566-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD124 / IL4R - H00003566-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD124 / IL4R - P3682 from Acris Antibodies Category Protein Prices $580.00 Sizes 10 µg Species Human

CD124 / IL4R - P6153 from Acris Antibodies Category Protein Prices $580.00 Sizes 15 µg Species Human

Soluble IL-4 receptor alpha, sIL-4R alpha, Human, Recombinant - 28-10004sr from ARP American Research Products Category Protein Prices $99.00, $199.00 Sizes 3 µg, 15 µg Source HEK293 cells Species Human

CD124 Recombinant Protein - 96-472 from ProSci Category Protein Prices $400.00 Sizes 50 µg Source HEK293 cells Species Human

Soluble IL-4 Receptor alpha Recombinant Protein - 40-247 from ProSci Category Protein Prices $130.00, $225.00 Sizes 3 µg, 15 µg Source HEK293 cells Species Human

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