CD68

Gene Symbol	CD68
Entrez Gene	968
Alt Symbol	GP110, LAMP4, SCARD1
Species	Human
Gene Type	protein-coding
Description	CD68 molecule
Other Description	CD68 antigen|macrophage antigen CD68|macrosialin|scavenger receptor class D, member 1
Swissprots	P34810 Q53XI3 Q53HR6 Q96BI7 B4DVT4
Accessions	AAC70006 EAW90165 P34810 AK222492 BAD96212 AK222514 BAD96234 AK290238 BAF82927 AK298055 BAG60349 AK301223 BAG62796 AW294871 BC015557 AAH15557 BT009923 AAP88925 BX438711 BX647524 DB187273 DQ890631 ABM92248 DQ893801 ABM84727 S57235 AAB25811 NM_001040059 NP_001035148 NM_001251 NP_001242
Function	Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Subcellular Location	Isoform Short: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. {ECO:0000269|PubMed:18405323}.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD68-Over-expression-Lysate - LY11438a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CD68 overexpression lysate - LY420047 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CD68 overexpression lysate - LY421888 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CD68 overexpression lysate - LY425673 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CD68 293 Cell Lysate - 409387 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CD68/SR-D1 Overexpression Lysate (Native) - NBL1-08962 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CD68 (h): 293T Lysate - sc-175248 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CD68 Over-expression Lysate Product - GWB-A5C35C from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human CD68 / Macrosialin / Gp110 (aa 1-319) Insect Cell Lysate (WB positive control) - 11192-H08B1L-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human CD68 / Macrosialin / Gp110 HEK293 Cell Lysate (WB positive control) - 11192-H03HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

CD68/SR-D1 Overexpression Lysate (Denatured) - H00000968-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human CD68 Human Cells Transfected Lysate (positive control) (denatured) - orb173471 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human CD68 (aa 1-319) Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175570 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

CD68-knockout Cell lysate - LC810037 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human CD68 Knockdown Stable Cell Line - CSC-DC002765 from Creative biogene Category Cell Line Species Human

Human CD68 Knockout Cell Line-HeLa - CSC-RT0498 from Creative biogene Category Cell Line Species Human

CD68 KO Cell Lysate-HeLa - CLKO-0003 from Creative biogene Category Cell Lysate

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