ENPP1

Gene Symbol	ENPP1
Entrez Gene	5167
Alt Symbol	ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1
Species	Human
Gene Type	protein-coding
Description	ectonucleotide pyrophosphatase/phosphodiesterase 1
Other Description	E-NPP 1|Ly-41 antigen|alkaline phosphodiesterase 1|ectonucleotide pyrophosphatase/phosphodiesterase family member 1|membrane component chromosome 6 surface marker 1|membrane component, chromosome 6, surface marker 1|phosphodiesterase I/nucleotide pyrophosphatase 1|plasma-cell membrane glycoprotein 1|plasma-cell membrane glycoprotein PC-1
Swissprots	Q9NPZ3 Q5T9R6 Q9Y6K3 Q9P1P6 P22413 Q9UP61
Accessions	AAD38420 AAD38421 AAF36094 BAA97562 CAC39442 EAW48041 EAW48042 P22413 AK314870 BAG37385 BC033008 BC059375 AAH59375 BX537580 CAD97789 D12485 BAA02054 M57736 AAA63237 XM_011535896 XP_011534198 NM_006208 NP_006199
Function	By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function. {ECO:0000269|PubMed:10615944, ECO:0000269|PubMed:8001561}.
Subcellular Location	Cell membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein. Secreted {ECO:0000250}. Note=The proteolytically processed form is secreted (By similarity). Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side. {ECO:0000250}.
Tissue Specificity	Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis. {ECO:0000269|PubMed:9344668}.
Top Pathways	Purine metabolism, Nicotinate and nicotinamide metabolism, Riboflavin metabolism, Pantothenate and CoA biosynthesis, Starch and sucrose metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ENPP1 ELISA Kit (Sandwich ELISA) - LS-F7513 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.062 ng/ml Range 0.156-10 ng/ml

Human ENPP1 ELISA Kit (Sandwich ELISA) - LS-F11375 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human ENPP1 ELISA Kit - abx151416 from Abbexa Category ELISA Kit Sensitivity 0.062 ng/ml Range 0.156 ng/ml - 10 ng/ml

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1), Human, ELISA Kit - SEF219Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.062ng/mL Range 0.156-10ng/mL

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1), Human, ELISA Kit - CSB-EL007679HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, ENPP1, Human, ELISA Kit - E1032h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1, ELISA Kit - MBS091913 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1, ELISA Kit - MBS055088 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1, ELISA Kit - MBS091249 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1, ELISA Kit - MBS052084 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1, ELISA Kit - MBS064663 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1, ELISA Kit - MBS088478 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.25ng/ml-8ng/ml.

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1, ELISA Kit - MBS054211 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ectonucleotide pyrophosphatase/phosphodiesterase 1, ELISA Kit - MBS909816 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1), ELISA Kit - MBS2024319 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.062ng/mL. Range 0.156-10ng/mL

ELISA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) - SEF219Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.062ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 1(ENPP1) EL - CSB-EL007679HU from Cusabio Sensitivity Request Information Range Request Information

ELISA Kit for Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) - SEF219Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.062ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse ENPP1 ELISA Kit (Custom ELISA) - LS-F15692 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) ELISA Kit - EKU03829 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.063 ng/mL Range 0.156-10 ng/mL

Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ELISA Kit - abx250408 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Rat ENPP1 ELISA Kit (Sandwich ELISA) - LS-F13164 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 31.2 Range 0.156-10 ng/ml

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1), Human, ELISA Kit - DL-ENPP1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human ENPP1 ELISA Kit - abx571111 from Abbexa Category ELISA Kit Sensitivity 0.062 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) ELISA Kit - EKC33535 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 1.56 ng/ml Range 6.25 ng/ml-400 ng/ml

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