| Gene Symbol | ENPP1 |
|---|---|
| Entrez Gene | 5167 |
| Alt Symbol | ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| Other Description | E-NPP 1|Ly-41 antigen|alkaline phosphodiesterase 1|ectonucleotide pyrophosphatase/phosphodiesterase family member 1|membrane component chromosome 6 surface marker 1|membrane component, chromosome 6, surface marker 1|phosphodiesterase I/nucleotide pyrophosphatase 1|plasma-cell membrane glycoprotein 1|plasma-cell membrane glycoprotein PC-1 |
| Swissprots | Q9NPZ3 Q5T9R6 Q9Y6K3 Q9P1P6 P22413 Q9UP61 |
| Accessions | AAD38420 AAD38421 AAF36094 BAA97562 CAC39442 EAW48041 EAW48042 P22413 AK314870 BAG37385 BC033008 BC059375 AAH59375 BX537580 CAD97789 D12485 BAA02054 M57736 AAA63237 XM_011535896 XP_011534198 NM_006208 NP_006199 |
| Function | By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function. {ECO:0000269|PubMed:10615944, ECO:0000269|PubMed:8001561}. |
| Subcellular Location | Cell membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein. Secreted {ECO:0000250}. Note=The proteolytically processed form is secreted (By similarity). Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side. {ECO:0000250}. |
| Tissue Specificity | Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis. {ECO:0000269|PubMed:9344668}. |
| Top Pathways | Purine metabolism, Nicotinate and nicotinamide metabolism, Riboflavin metabolism, Pantothenate and CoA biosynthesis, Starch and sucrose metabolism |
PC-1 CRISPR/Cas9 KO Plasmid (h) - sc-402336 from Santa Cruz Biotechnology
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PC-1 HDR Plasmid (h) - sc-402336-HDR from Santa Cruz Biotechnology
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PC-1 Double Nickase Plasmid (h) - sc-402336-NIC from Santa Cruz Biotechnology
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PC-1 Double Nickase Plasmid (h2) - sc-402336-NIC-2 from Santa Cruz Biotechnology
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PC-1 CRISPR Activation Plasmid (h) - sc-402336-ACT from Santa Cruz Biotechnology
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PC-1 CRISPR Activation Plasmid (h2) - sc-402336-ACT-2 from Santa Cruz Biotechnology
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PC-1 Lentiviral Activation Particles (h) - sc-402336-LAC from Santa Cruz Biotechnology
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PC-1 Lentiviral Activation Particles (h2) - sc-402336-LAC-2 from Santa Cruz Biotechnology
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PC-1 siRNA (h) - sc-40811 from Santa Cruz Biotechnology
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PC-1 shRNA Plasmid (h) - sc-40811-SH from Santa Cruz Biotechnology
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PC-1 shRNA (h) Lentiviral Particles - sc-40811-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU145971 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0162 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0160 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7880 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7880 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06027 from Sigma-Aldrich
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ENPP1 siRNA (Human) - CRH3447 from Cohesion Biosciences
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ENPP-1 RNAi - H00005167-R02 from Novus Biologicals
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ENPP1 - MBS8205152 from MyBioSource
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shRNA set against Human ENPP1 (NM_006208.2) - SHH285913 from Creative biogene
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Human ENPP1 siRNA - orb263949 from Biorbyt
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ENPP1 shRNA Plasmid (Human) - CHH3447 from Cohesion Biosciences
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