ABCC1

Gene Symbol ABCC1
Entrez Gene 4363
Alt Symbol ABC29, ABCC, GS-X, MRP, MRP1
Species Human
Gene Type protein-coding
Description ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Other Description ATP-binding cassette transporter variant ABCC1delta-ex13|ATP-binding cassette transporter variant ABCC1delta-ex13&14|ATP-binding cassette transporter variant ABCC1delta-ex25|ATP-binding cassette transporter variant ABCC1delta-ex25&26|LTC4 transporter|leukotriene C(4) transporter|multidrug resistance-associated protein 1
Swissprots Q9UQ97 P78419 O43333 P33527 Q9UQ99 Q59GI9 C9JPJ4 O14819 A3RJX2 Q9UQA0
Accessions AAB82786 AAB83979 AAB83980 AAB83981 AAB83982 AAB83983 AAC05808 AAC15784 ABN79590 EAW53936 EAW53937 EAW53938 EAW53939 EAW53940 EAW53941 EAW53942 EAW53943 EAW53944 EAW53945 EAW53946 EAW53947 EAW53948 EAW53949 P33527 AB209120 BAD92357 AJ003198 AK311015 BC001636 AAH01636 BC156353 AAI56354 BC157105 AAI57106 BX648866 CR749835 CAH18691 HQ917064 AEK86268 HQ917065 AEK86269 HQ917066 AEK86270 HQ917067 AEK86271 L05628 AAB46616 X78338 XM_011522497 XP_011520799 XM_011522498 XP_011520800 NM_004996 NP_004987 NM_019862 NM_019898 NM_019899 NM_019900 NM_019901 NM_019902
Function Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. {ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:16230346}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:16230346}.
Tissue Specificity Lung, testis and peripheral blood mononuclear cells.
Top Pathways ABC transporters, Vitamin digestion and absorption, MicroRNAs in cancer, Sphingolipid signaling pathway

MRP1/ABCC1 (D7O8N) Rabbit mAb - 14685 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7O8N
Western blot analysis of extracts from A-549, PANC-1, and Hep G2 cells using MRP1/ABCC1 (D7O8N) Rabbit mAb.

MRP1/ABCC1 Antibody - 14198 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from PANC-1 and A549 cells using MRP1/ABCC1 Antibody

MRP (T-24) - sc-28287 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MRP1 (E-5) - sc-365635 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MRP1 (E-5): sc-365635. Western blot analysis of MRP1 expression in H69AR whole cell lysate.

MRP1 (C-20) - sc-7773 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MRP1 (C-20): sc-7773. Western blot analysis of MRP1 expression in T98G (A), A549 (B), AML-193 (C), H69AR (D) and HeLa (E) whole cell lysates.

MRP1 (E-7) - sc-365990 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MRP1 (E-7): sc-365990. Western blot analysis of MRP1 expression in H69AR whole cell lysate.

MRP1 (H-70) - sc-13960 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MRP1 (H-70): sc-13960. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing membrane and cytoplasmic staining of cells in seminiferous ducts.

MRP1 (IU2H10) - sc-53130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MRP1 (IU2H10): sc-53130. Western blot analysis of MRP1 expression in H69AR whole cell lysate.

MRP1 (N-19) - sc-7774 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MRP1 (N-19): sc-7774. Western blot analysis of human recombinant MRP1 fusion protein.

MRP1 (QCRL-1) - sc-18835 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MRP1 (QCRL-1): sc-18835. Western blot analysis of MRP1 expression in T98G (A), A549 (B) and AML-193 (C) whole cell lysates.

MRP1 (QCRL-2) - sc-18836 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MRP1 (QCRL-2) FITC: sc-18836 FITC. FCM analysis of HL-60/MX1 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>2b</sub>: sc-2857.

MRP1 (QCRL-4) - sc-18874 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MRP1 (QCRL-4) PE: sc-18874 PE. FCM analysis of H69AR cells. Quadrant markers were set based on the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

MRP1 (QRCL-3) - sc-18873 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MRP1 (QCRL-3): sc-18873. Immunofluorescence staining of methanol-fixed T98G cells showing membrane localization.

MRP1 (9) - sc-136447 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MRP1 (9): sc-136447. Western blot analysis of MRP1 expression in WI-38 whole cell lysate.

Anti-MRP1 antibody [EPR4658(2)] - C-terminal - ab180960 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4658(2)
Flow cytometric analysis of 2% paraformaldehyde fixed HeLa cells labeling MRP1 using ab180960 at 1/10 dilution (green) or Rabbit monoclonal IgG (red) followed by Goat anti rabbit IgG (FITC) at 1/150 dilution.

Anti-MRP1 antibody [IU2H10] - ab32574 from Abcam

Prices $382.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone IU2H10
All lanes : Anti-MRP1 antibody [IU2H10] (ab32574)Lane 1 : Vector-transfected HEK293 cellsLane 2 : MRP1-transfected cells, prep1Lane 3 : MRP1-transfected cells, prep2 (the lower band is a degradation product)

Anti-MRP1 antibody [MRPm5] - ab24102 from Abcam

Prices $394.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone MRPm5
ICC/IF image of Anti-MRP1 antibody (ab24102) stained human ES cell derived hepatocytes. The cells were fixed in methanol, blocked and permeabilized using 10% BSA in PBS/0.1% Tween, for 1 hour at 20oC. The cells were then incubated with ab24102 at a 1/50 dilution for 16 hours at 4oC. The secondary antibody was a Donkey anti-Mouse Alexa Fluor 488, used at a 1/400 dilution.See Abreview

Anti-MRP1 antibody [MRPr1] - ab3368 from Abcam

Prices $384.00
Sizes 250 µl
Host Rat
Clonality Monoclonal
Clone MRPr1
ICC/IF image of ab3368 stained HepG2 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab3368,5µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rat IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-MRP1 antibody [QCRL1] - ab3369 from Abcam

Prices $373.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone QCRL1

Anti-MRP1 antibody - N-terminal - ab137406 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-MRP1 antibody - N-terminal (ab137406) at 1/1000 dilution + A431 whole cell lysate at 30 µg

MRP1 Antibody (IU2H10) - NB400-156 from Novus Biologicals

Prices $99.00, $329.00, $929.00
Sizes 25 µl, 100 µl, 1 ml
Host Mouse
Clonality Monoclonal
Clone IU2H10
Western Blot: MRP1 Antibody (IU2H10) [NB400-156] - Vector-transfected HEK293 cells 2: MRP1-transfected cells, prep1 3: MRP1-transfected cells, prep2 (the lower band is a degradation product.

MRP1 Antibody (IU5C1) - NB110-57131 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Mouse
Clonality Monoclonal
Clone IU5C1
Western Blot: MRP1 Antibody (IU5C1) [NB110-57131] - Detection of MRP1 in 10 ug of 293 transfected (lane 2) and empty vector (lane 1) lysate.

MRP1 Antibody (464510) [Unconjugated] - MAB1929 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 464510
Human blood‑derived lymphocytes were stained with Mouse Anti-Human MRP1 Monoclonal Antibody (Catalog # MAB1929, filled histogram) or isotype control antibody (Catalog # MAB0031, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG F(ab')2 Secondary Antibody (Catalog # F0101B). To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin.

MRP1 Antibody - NBP1-20870 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: MRP1 Antibody [NBP1-20870] - (0.05ug/ml) staining of A549 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

MRP1 Antibody (IU2H10) [Alexa Fluor (R) 700] - NB400-156AF700 from Novus Biologicals

Prices $289.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone IU2H10
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