CDC25B
| Gene Symbol | CDC25B |
|---|---|
| Entrez Gene | 994 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell division cycle 25B |
| Other Description | M-phase inducer phosphatase 2|dual specificity phosphatase Cdc25B |
| Swissprots | Q5JX77 O43551 D3DVY1 P30305 D3DVY2 Q13971 D3DVY4 Q6RSS1 D3DVY3 Q9BRA6 |
| Accessions | AAB94622 AAB94623 AAB94624 AAB94625 AAR26469 CAA65303 EAX10491 EAX10493 EAX10494 EAX10496 EAX10498 EAX10499 EAX10500 EAX10501 P30305 AK092713 BAG52600 AK124284 AK295573 BAG58472 AK299028 BAG61105 AK299192 BAG61235 AL561439 BC006395 AAH06395 BC009953 AAH09953 BC051711 AAH51711 BM793120 BX640836 CAE45909 BX647988 DA065196 DA107932 DB477384 FR695900 CBX26628 FR695901 CBX26629 M81934 AAA58416 S78187 AAB21139 Z68092 CAA92108 XR_937181 NM_001287516 NP_001274445 NM_001287517 NP_001274446 NM_001287518 NP_001274447 NM_001287519 NP_001274448 NM_001287520 NP_001274449 NM_001287522 NP_001274451 NM_001287524 NP_001274453 NM_004358 NP_004349 NM_021872 NP_068658 NM_021873 NP_068659 NM_021874 NM_212530 |
| Function | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. {ECO:0000269|PubMed:17332740}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. |
| Top Pathways | Cell cycle, Progesterone-mediated oocyte maturation, MAPK signaling pathway, MicroRNAs in cancer |
Cdc25B CRISPR/Cas9 KO Plasmid (h) - sc-401457 from Santa Cruz Biotechnology
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Cdc25B HDR Plasmid (h) - sc-401457-HDR from Santa Cruz Biotechnology
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Cdc25B Double Nickase Plasmid (h) - sc-401457-NIC from Santa Cruz Biotechnology
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Cdc25B Double Nickase Plasmid (h2) - sc-401457-NIC-2 from Santa Cruz Biotechnology
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Cdc25B CRISPR Activation Plasmid (h) - sc-401457-ACT from Santa Cruz Biotechnology
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Cdc25B CRISPR Activation Plasmid (h2) - sc-401457-ACT-2 from Santa Cruz Biotechnology
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Cdc25B Lentiviral Activation Particles (h) - sc-401457-LAC from Santa Cruz Biotechnology
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Cdc25B Lentiviral Activation Particles (h2) - sc-401457-LAC-2 from Santa Cruz Biotechnology
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Cdc25B siRNA (h) - sc-37552 from Santa Cruz Biotechnology
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Cdc25B shRNA Plasmid (h) - sc-37552-SH from Santa Cruz Biotechnology
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Cdc25B shRNA (h) Lentiviral Particles - sc-37552-V from Santa Cruz Biotechnology
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CDC25B RNAi - H00000994-R05 from Novus Biologicals
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CDC25B RNAi - H00000994-R04 from Novus Biologicals
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MISSION® esiRNA - EHU072881 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0929 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0058 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0060 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0059 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1374 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1232 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1374 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1232 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08945 from Sigma-Aldrich
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CDC25B siRNA (Human) - CRH0708 from Cohesion Biosciences
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CDC25B RNAi - H00000994-R03 from Novus Biologicals
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