SLC12A7

Gene Symbol SLC12A7
Entrez Gene 10723
Alt Symbol KCC4
Species Human
Gene Type protein-coding
Description solute carrier family 12 (potassium/chloride transporter), member 7
Other Description K-Cl cotransporter 4|electroneutral potassium-chloride cotransporter 4|potassium/chloride transporter KCC4|solute carrier family 12 (potassium/chloride transporters), member 7|solute carrier family 12 member 7
Swissprots A6NDS8 Q9H7I3 Q9Y666 Q4G0F3 Q9H7I7 Q9UFW2 Q96I81
Accessions CAH25944 EAX08178 EAX08179 EAX08180 EAX08181 Q9Y666 AF105365 AAD39741 AK024493 BAB15783 AK024497 BAB15787 AK026625 AK302856 BAG64042 AL117433 CAB55921 BC007760 AAH07760 BC018982 BC098390 AAH98390 BU953746 DB451347 XM_005248231 XP_005248288 XM_006725006 XP_006725069 XM_011513939 XP_011512241 XM_011513940 XP_011512242 XM_011513941 XP_011512243 XM_011546472 XP_011544774 XM_011546473 XP_011544775 XM_011546474 XP_011544776 XR_925579 XR_925580 XR_925582 XR_951676 XR_951677 XR_951678 NM_006598 NP_006589
Function Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Detected in muscle, brain, lung, heart and kidney.
Top Pathways Collecting duct acid secretion

KCC4 (C-12) - sc-19427 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

KCC4 (H-44) - sc-368187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

KCC4 (L-13) - sc-19426 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KCC4 (L-13): sc-19426. Western blot analysis of KCC4 expression in U-251-MG (A), Sol8 (B) and KNRK (C) whole cell lysates.

Anti-KCC4 antibody - ab78912 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-KCC4 antibody - ab168941 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-KCC4 antibody (ab168941) at 1 µg/mlLane 1 : KCC4 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-mouse IgG at 1/2500 dilution

Anti-KCC4 antibody - ab96424 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-KCC4 antibody (ab96424) at 1/500 dilution + H1299 whole cell lysate at 30 µg

Anti-KCC4 antibody - N-terminal - ab170623 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue labeling KCC4 with ab170623 at 1/10 dilution followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-SLC12A7 / KCC4 Antibody (N-Terminus) - LS-C16129 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC12A7 / KCC4 Antibody (N-Terminal) - LS-C16130 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A7 / KCC4 Antibody (C-Terminus) - LS-C37120 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC12A7 / KCC4 Antibody (aa951-962) - LS-C55026 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SLC12A7 / KCC4 Antibody (Internal) - LS-C145145 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A7 / KCC4 Antibody (aa96-125, AP) - LS-C224082 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A7 / KCC4 Antibody (aa96-125, APC) - LS-C224083 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A7 / KCC4 Antibody (aa96-125, Biotin) - LS-C224084 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A7 / KCC4 Antibody (aa96-125, FITC) - LS-C224085 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A7 / KCC4 Antibody (aa96-125, Azide-free, HRP) - LS-C224086 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A7 / KCC4 Antibody (aa96-125, PE) - LS-C224087 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A7 / KCC4 Antibody (aa96-125) - LS-C330142 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC12A7 / KCC4 Antibody (aa950-1000) - LS-C291078 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human KCC4 by Western Blot. Samples: Whole cell lysate (50 ug) prepared using NETN buffer from Jurkat cells. Antibodies: Affinity purified rabbit anti-KCC4 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-SLC12A7 / KCC4 Antibody (aa1-50) - LS-C291079 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human KCC4 by Western Blot. Samples: Whole cell lysate (50 ug) prepared using NETN buffer from Jurkat cells. Antibodies: Affinity purified rabbit anti-KCC4 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-SLC12A7 / KCC4 Antibody (aa845-1083) - LS-C185497 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: H1299. 7.5% SDS PAGE. KCC4 antibody diluted at 1:500

Anti-SLC12A7 / KCC4 Antibody (aa89-117) - LS-C161130 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SLC12A7 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human heart tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

KCC4/SLC12A7 Antibody - NBP1-85133 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KCC4/SLC12A7 Antibody - H00010723-B01 from Novus Biologicals

Host Mouse
Clonality Polyclonal
Western Blot: KCC4/SLC12A7 Antibody [H00010723-B01] - analysis of SLC12A7 expression in transfected 293T cell line by SLC12A7 MaxPab polyclonal antibody. Lane 1: SLC12A7 transfected lysate (14.20 KDa). Lane 2: Non-transfected lysate.
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