Gene Symbol | Zap70 |
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Entrez Gene | 22637 |
Alt Symbol | Srk, ZAP-70, mrtle, mur |
Species | Mouse |
Gene Type | protein-coding |
Description | zeta-chain (TCR) associated protein kinase |
Other Description | 70 kDa zeta-chain associated protein|syk-related tyrosine kinase|tyrosine-protein kinase ZAP-70 |
Swissprots | P97455 Q80VV2 Q8CHJ3 P43404 |
Accessions | EDL14509 EDL14510 P43404 AB083210 BAC43746 AB084383 BAC67015 AK039883 BAC30471 AK089056 BC029727 AAH29727 BY589032 CJ143180 U04379 AAA19250 U77667 AAB36538 XM_006495896 XP_006495959 NM_001289612 NP_001276541 NM_001289765 NP_001276694 NM_001289766 NP_001276695 NM_009539 NP_033565 |
Function | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion |
Subcellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In quiescent T-lymphocytes, ZAP70 is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes. |
Tissue Specificity | Isoform 1 and isoform 2 are expressed in thymus, spleen and lymph nodes. {ECO:0000269|PubMed:14985102}. |
Top Pathways | Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Primary immunodeficiency |
Anti-ZAP70 antibody produced in rabbit - SAB2107611 from Sigma-Aldrich
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Anti-Zap-70 (11H40) Antibody (OAED00015) - OAED00015 from Aviva Systems Biology
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Zap70 antibody - middle region (ARP61185_P050) - ARP61185_P050 from Aviva Systems Biology
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Mouse-Zap70-Antibody-C-term - AP16081b from Abgent, a WuXi AppTec company
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Zap70-Antibody - AM8462b from Abgent, a WuXi AppTec company
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Mouse Zap70 Antibody - C-terminal region (OAAB11481) - OAAB11481 from Aviva Systems Biology
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ZAP70 antibody - orb32253 from Biorbyt
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Zap70 antibody (Tyr493) - 70R-37237 from Fitzgerald
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ZAP70 antibody (Tyr493) - 70R-32566 from Fitzgerald
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ZAP70 antibody - 70R-35228 from Fitzgerald
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Zap70 antibody (Tyr319) - 70R-37236 from Fitzgerald
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ZAP70 antibody (Tyr319) - 70R-32565 from Fitzgerald
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zAP70 Antibody - abx104321 from Abbexa
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PE anti-human/mouse ZAP-70 Antibody - 313403 from Biolegend
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Purified anti-human/mouse ZAP-70 Antibody - 313402 from Biolegend
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FITC anti-human/mouse ZAP-70 Antibody - 313406 from Biolegend
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Anti-ZAP70 antibody - STJ72750 from St John's Laboratory Ltd
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ZAP 70, Polyclonal Antibody - MBS629798 from MyBioSource
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ZAP 70, Polyclonal Antibody - MBS625718 from MyBioSource
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ZAP 70, Polyclonal Antibody - MBS630330 from MyBioSource
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ZAP 70, Polyclonal Antibody - MBS629312 from MyBioSource
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ZAP 70, Polyclonal Antibody - MBS624732 from MyBioSource
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ZAP 70, Polyclonal Antibody - MBS625553 from MyBioSource
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ZAP 70, aa326-341 - MBS644921 from MyBioSource
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ZAP 70 - MBS633462 from MyBioSource
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