| Gene Symbol |
Zap70
|
| Entrez Gene |
22637
|
| Alt Symbol |
Srk, ZAP-70, mrtle, mur
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
zeta-chain (TCR) associated protein kinase
|
| Other Description |
70 kDa zeta-chain associated protein|syk-related tyrosine kinase|tyrosine-protein kinase ZAP-70
|
| Swissprots |
P97455 Q80VV2 Q8CHJ3 P43404
|
| Accessions |
EDL14509 EDL14510 P43404 AB083210 BAC43746 AB084383 BAC67015 AK039883 BAC30471 AK089056 BC029727 AAH29727 BY589032 CJ143180 U04379 AAA19250 U77667 AAB36538 XM_006495896 XP_006495959 NM_001289612 NP_001276541 NM_001289765 NP_001276694 NM_001289766 NP_001276695 NM_009539 NP_033565
|
| Function |
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion
|
| Subcellular Location |
Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In quiescent T-lymphocytes, ZAP70 is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are expressed in thymus, spleen and lymph nodes. {ECO:0000269|PubMed:14985102}.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Primary immunodeficiency
|