BCL2L11

Gene Symbol BCL2L11
Entrez Gene 10018
Alt Symbol BAM, BIM, BOD
Species Human
Gene Type protein-coding
Description BCL2-like 11 (apoptosis facilitator)
Other Description bcl-2 interacting mediator of cell death|bcl-2 interacting protein Bim|bcl-2-like protein 11|bcl-2-related ovarian death agonist
Swissprots Q8WYL6 O43522 Q6TE16 Q6JTU6 Q6TE15 O43521 Q8WYL9 Q53R28 Q6TE14 Q8WYM1 Q8WYM0 A8K2W2 Q0MSE9 Q0MSE8 Q8WYL7 Q8WYL8 Q6T851 Q6V402 Q0MSE7
Accessions AAY14797 CBX53894 CEF39446 EAW50364 EAW50365 EAW50366 EAW50367 EAW50369 EAW50370 EAW50371 EAW50372 EAW50373 EAW50374 O43521 AA854054 AA890664 AB071195 BAB78589 AB071196 BAB78590 AB071197 BAB78591 AB071198 BAB78592 AB071199 BAB78593 AB071200 BAB78594 AF032457 AAC39593 AF032458 AAC39594 AF086141 AF455755 AAL57868 AI268146 AK027160 AK290377 BAF83066 AK291269 BAF83958 AW629314 AY305714 AAQ82546 AY305715 AAQ82547 AY305716 AAT34900 AY352518 AAQ62569 AY423441 AAQ99148 AY423442 AAQ99149 AY423443 AAQ99150 AY428962 AAR06908 BC033694 AAH33694 CN411912 DQ849200 ABI13589 DQ849201 ABI13590 DQ849202 ABI13591 HQ447452 ADQ31938 XM_005263550 XP_005263607 XM_005263551 XP_005263608 XM_005263552 XP_005263609 XM_005263553 XP_005263610 XM_005263554 XP_005263611 XM_005263555 XP_005263612 XM_005263556 XP_005263613 XM_005263557 XP_005263614 XM_005263559 XP_005263616 XM_005263561 XP_005263618 XM_011510461 XP_011508763 XM_011510462 XP_011508764 XM_011510463 XP_011508765 XM_011510464 XP_011508766 XM_011510465 XP_011508767 XR_244801 XR_244802 XR_922828 XR_922829 XR_922830 NM_001204106 NP_001191035 NM_001204107 NP_001191036 NM_001204108 NP_001191037 NM_001204109 NP_001191038 NM_001204110 NP_001191039 NM_001204111 NP_001191040 NM_001204112 NP_001191041 NM_001204113 NP_001191042 NM_006538 NP_006529 NM_138621 NP_619527 NM_138622 NP_619528 NM_138623 NP_619529 NM_138624 NP_619530 NM_138625 NP_619531 NM_138626 NP_619532 NM_138627 NP_619533 NM_207002 NP_996885 NM_207003 NP_996886
Function Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:9430630}.
Subcellular Location Isoform Bim-alpha1: Mitochondrion.
Tissue Specificity Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. {ECO:0000269|PubMed:12019181}.
Top Pathways PI3K-Akt signaling pathway, MicroRNAs in cancer, Non-alcoholic fatty liver disease (NAFLD)

Bim (C34C5) Rabbit mAb (PE Conjugate) - 12186 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone C34C5
Flow cytometric analysis of HeLa cells using Bim (C34C5) Rabbit mAb (PE Conjugate) (green) compared to concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control (PE Conjugate) #5742 (red).

Phospho-Bim (Ser69) (D7E11) Rabbit mAb - 4585 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7E11
Western blot analysis of extracts from Raji cells, untreated or TPA-treated for 30 min, using Phospho-Bim (Ser69) (D7E11) Rabbit mAb (upper) or total Bim (C34C5) Rabbit mAb #2933 (lower).

Phospho-Bim (Ser69) Antibody - 4581 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Raji cells, untreated or TPA-treated for 30 min, using Phospho-Bim (Ser69) Antibody (upper), or Bim Antibody #2819 (lower).

Phospho-Bim (Ser77) (D4H12) Rabbit mAb - 12433 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4H12
Western blot analysis of extracts from Raji and MCF7 cells, untreated (-) or treated with TPA #4174 (200 nM, 30 min; +), using Phospho-Bim (Ser77) (D4H12) Rabbit mAb (upper) or Bim (C34C5) Rabbit mAb #2933 (lower).

Bim Antibody - 2819 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from MOLT-4, A20, Raji, 293 and MCF-7 cell lines using Bim Antibody.

Bim (C34C5) Rabbit mAb - 2933 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C34C5
Western blot analysis of extracts from Raji, A20 and RL-7 cells using Bim (C34C5) Rabbit mAb.

Bim Antibody - 4582 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HuT-78, 293, and MCF-10a cells, showing the three major isoforms of Bim, using the Bim Antibody

Bim (N-20) - sc-8265 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bim (N-20): sc-8265. Western blot analysis of Bim expression in HuT 78 whole cell lysate.

Bim (H-5) - sc-374358 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bim (H-5): sc-374358. Western blot analysis of Bim expression in non-transfected: sc-117752 (A) and mouse Bim transfected: sc-126502 (B) 293T whole cell lysates.

Bim (M-20) - sc-8267 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bim (M-20): sc-8267. Immunoperoxidase staining of formalin fixed, paraffin-embedded human smooth muscle tissue showing cytoplasmic staining of smooth muscle cells.

Bim (H-191) - sc-11425 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bim (H-191): sc-11425. Western blot analysis of Bim isoform expression in HuT 78 whole cell lysate.

Bim (D-17) - sc-31687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bim (D-17): sc-31687. Western blot analysis of human recombinant Bim fusion protein.

Bim EL (N-17) - sc-27982 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bim<sub>EL</sub> (N-17): sc-27982. Western blot analysis of human recombinant Bim<sub>EL</sub> fusion protein.

p-Bim EL/L (Ser 65) - sc-101646 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Bim<sub>EL/L</sub> (Ser 65): sc-101646. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytolasmic staining.

Anti-Bim (phospho S59) antibody - ab112106 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab112106, at a 1/50 dilution, staining Bim in Paraffin-embedded Human brain tissue by Immunohistochemistry, in the absence (left) and presence (right) of the phosphopeptide.

Anti-Bim (phospho S65) antibody - ab17935 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Bim (phospho S69) antibody - ab131477 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of methanol-fixed HeLa cells labelling Bim (phospho S69) with ab131477 at 1/100 dilution.

Anti-Bim antibody - ab7888 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Bim antibody (ab7888) at 1 µg/mlLane 1 : K562 whole cell lysateLane 2 : A549 whole cell lysate

Anti-Bim antibody - ab15184 from Abcam

Prices $378.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab15184, at 1:25 dilution, staining Bim in human placenta by Immunohistochemistry (Formalin/ PFA fixed paraffin embedded tissue sections).

Anti-Bim antibody - ab17031 from Abcam

Prices $378.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Bim antibody (ab17031) at 0.5 µg/ml + Cell lysates prepared from Human K562 cells at 35 µg

Anti-Bim antibody - ab53155 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Bim antibody (ab53155) at 1/500 dilutionLane 1 : extracts from COS7 cells, untreated.Lane 2 : extracts from COS7 cells, treated with the immunizing peptide.

Anti-Bim antibody [1C2H4] - ab181001 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C2H4
Anti-Bim antibody [1C2H4] (ab181001) at 1 µg/ml + Recombinant Bim protein at 0.005 µg

Anti-Bim antibody, prediluted - ab15185 from Abcam

Prices $370.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal

Anti-Bim antibody [Y36] - ab32158 from Abcam

Prices $403.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y36
Anti-Bim antibody [Y36] (ab32158) at 1/500 dilution + A431 cell lysate

Anti-Bim antibody [Y36] (Alexa Fluor® 488) - ab200667 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y36
ab200667 staining Bim in MCF7 cells. The cells were fixed with 4% formaldehyde (10min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab200667 at 1/200 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at 2µg/ml (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).
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