| Gene Symbol | BCL2L11 |
|---|---|
| Entrez Gene | 10018 |
| Alt Symbol | BAM, BIM, BOD |
| Species | Human |
| Gene Type | protein-coding |
| Description | BCL2-like 11 (apoptosis facilitator) |
| Other Description | bcl-2 interacting mediator of cell death|bcl-2 interacting protein Bim|bcl-2-like protein 11|bcl-2-related ovarian death agonist |
| Swissprots | Q8WYL6 O43522 Q6TE16 Q6JTU6 Q6TE15 O43521 Q8WYL9 Q53R28 Q6TE14 Q8WYM1 Q8WYM0 A8K2W2 Q0MSE9 Q0MSE8 Q8WYL7 Q8WYL8 Q6T851 Q6V402 Q0MSE7 |
| Accessions | AAY14797 CBX53894 CEF39446 EAW50364 EAW50365 EAW50366 EAW50367 EAW50369 EAW50370 EAW50371 EAW50372 EAW50373 EAW50374 O43521 AA854054 AA890664 AB071195 BAB78589 AB071196 BAB78590 AB071197 BAB78591 AB071198 BAB78592 AB071199 BAB78593 AB071200 BAB78594 AF032457 AAC39593 AF032458 AAC39594 AF086141 AF455755 AAL57868 AI268146 AK027160 AK290377 BAF83066 AK291269 BAF83958 AW629314 AY305714 AAQ82546 AY305715 AAQ82547 AY305716 AAT34900 AY352518 AAQ62569 AY423441 AAQ99148 AY423442 AAQ99149 AY423443 AAQ99150 AY428962 AAR06908 BC033694 AAH33694 CN411912 DQ849200 ABI13589 DQ849201 ABI13590 DQ849202 ABI13591 HQ447452 ADQ31938 XM_005263550 XP_005263607 XM_005263551 XP_005263608 XM_005263552 XP_005263609 XM_005263553 XP_005263610 XM_005263554 XP_005263611 XM_005263555 XP_005263612 XM_005263556 XP_005263613 XM_005263557 XP_005263614 XM_005263559 XP_005263616 XM_005263561 XP_005263618 XM_011510461 XP_011508763 XM_011510462 XP_011508764 XM_011510463 XP_011508765 XM_011510464 XP_011508766 XM_011510465 XP_011508767 XR_244801 XR_244802 XR_922828 XR_922829 XR_922830 NM_001204106 NP_001191035 NM_001204107 NP_001191036 NM_001204108 NP_001191037 NM_001204109 NP_001191038 NM_001204110 NP_001191039 NM_001204111 NP_001191040 NM_001204112 NP_001191041 NM_001204113 NP_001191042 NM_006538 NP_006529 NM_138621 NP_619527 NM_138622 NP_619528 NM_138623 NP_619529 NM_138624 NP_619530 NM_138625 NP_619531 NM_138626 NP_619532 NM_138627 NP_619533 NM_207002 NP_996885 NM_207003 NP_996886 |
| Function | Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:9430630}. |
| Subcellular Location | Isoform Bim-alpha1: Mitochondrion. |
| Tissue Specificity | Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. {ECO:0000269|PubMed:12019181}. |
| Top Pathways | PI3K-Akt signaling pathway, MicroRNAs in cancer, Non-alcoholic fatty liver disease (NAFLD) |