| Gene Symbol |
F2RL1
|
| Entrez Gene |
2150
|
| Alt Symbol |
GPR11, PAR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coagulation factor II (thrombin) receptor-like 1
|
| Other Description |
G-protein coupled receptor 11|coagulation factor II receptor-like 1|protease-activated receptor 2|proteinase-activated receptor 2|thrombin receptor-like 1
|
| Swissprots |
Q13317 Q53XJ8 Q13346 P55085
|
| Accessions |
AAA90957 AAK77914 CAA90290 CAV28807 EAW95782 P55085 AY336105 AAP97012 BC012453 AAH12453 BC018130 AAH18130 BT009856 AAP88858 DB463838 DQ890966 ABM81892 DQ894139 ABM85065 U34038 AAB47871 U67058 NM_005242 NP_005233
|
| Function |
Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumab
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle.
|
| Top Pathways |
African trypanosomiasis, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction
|
![Western Blot: PAR2 Overexpression Lysate (Adult Normal) [NBL1-10409] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PAR2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26236_PAR2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10409-img0002.jpg)