F2RL1

Gene Symbol	F2RL1
Entrez Gene	2150
Alt Symbol	GPR11, PAR2
Species	Human
Gene Type	protein-coding
Description	coagulation factor II (thrombin) receptor-like 1
Other Description	G-protein coupled receptor 11|coagulation factor II receptor-like 1|protease-activated receptor 2|proteinase-activated receptor 2|thrombin receptor-like 1
Swissprots	Q13317 Q53XJ8 Q13346 P55085
Accessions	AAA90957 AAK77914 CAA90290 CAV28807 EAW95782 P55085 AY336105 AAP97012 BC012453 AAH12453 BC018130 AAH18130 BT009856 AAP88858 DB463838 DQ890966 ABM81892 DQ894139 ABM85065 U34038 AAB47871 U67058 NM_005242 NP_005233
Function	Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumab
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle.
Top Pathways	African trypanosomiasis, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PAR2 full length protein - ab152372 from Abcam Category Protein Source Wheat germ Species Human

Human PAR2 protein fragment - ab152373 from Abcam Category Protein Source Wheat germ Species Human

F2RL1 / PAR2 Antibody Blocking Peptide - LS-E21986 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

F2RL1 / PAR2 Antibody Blocking Peptide - LS-E21987 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

F2RL1 / PAR2 Antibody Blocking Peptide - LS-E28565 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

F2RL1 / PAR2 Antibody Blocking Peptide - LS-E28566 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

F2RL1 / PAR2 Antibody Blocking Peptide - LS-E28567 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human PAR2 Protein - H00002150-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PAR2 Protein - H00002150-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

PAR2 Peptide - NBP2-11252 from Novus Biologicals Category Peptide Prices $229.00 Sizes 250 µg

PAR2 Recombinant Protein - H00002150-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

F2RL1 / GPR11 / PAR2 - H00002150-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

F2RL1 / GPR11 / PAR2 - H00002150-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

F2RL1 / GPR11 / PAR2 - H00002150-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

F2RL1 / GPR11 / PAR2 - H00002150-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

F2RL1 fusion protein - ag2801 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

F2RL1 fusion protein - ag9132 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PAR-2 (1-6) (mouse, rat) - 61700 from NeoScientific Category Peptide Prices $57.00, $85.00, $170.00 Sizes 5 mg, 10 mg, 25 mg Species Mouse

PAR-2(1-6) (human) - 89788 from NeoScientific Category Peptide Prices $51.00, $85.00, $170.00 Sizes 5 mg, 10 mg, 25 mg Species Human

Recombinant Protease Activated Receptor 2 (PAR2) - RPA852Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Protease Activated Receptor 2 (PAR2) - RPA852Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Protease Activated Receptor 2 (PAR2) - RPA852Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Protease Activated Receptor 2 (PAR2) - RPA852Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

ChemiSCREEN™ Membrane Preparation Recombinant Human PAR2 Protease-Activated Receptor - HTS037M from EMD Millipore Prices $596.00 Sizes 200 units Species Human

Recombinant Protease Activated Receptor 2 (PAR2) - RPA852Hu01 from Cloud-clone Category Protein Source E.coli Species Human

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