POLB

Gene Symbol	POLB
Entrez Gene	5423
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	polymerase (DNA directed), beta
Other Description	DNA pol beta|DNA polymerase beta|DNA polymerase beta subunit|mutant DNA polymerase beta
Swissprots	Q3KP48 P06746 B2RC78 Q6FI34
Accessions	AAA60134 AAB37517 AAB37518 AAB60688 AAL91594 CAA48603 EAW63221 P06746 AK223537 BAD97257 AK294025 BAH11651 AK314976 BAG37475 BC100288 AAI00289 BC106909 AAI06910 BM678092 BP370570 CR536503 CAG38741 CR541802 CAG46601 D29013 BAA06099 JQ664683 AFI72772 JQ927442 L11607 AAB59441 M13140 AAA60133 S69873 AAD14051 XM_005273535 XP_005273592 XM_005273536 XP_005273593 XM_005273537 XP_005273594 XM_005273538 XP_005273595 XM_005273539 XP_005273596 XM_005273540 XP_005273597 XM_006716353 XP_006716416 XR_428311 NM_002690 NP_002681
Function	Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. {ECO:0000269|PubMed:11805079, ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9572863}.
Subcellular Location	Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
Top Pathways	Base excision repair, HTLV-I infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DNA pol β (K-16) - sc-5927 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DNA pol β (H-147) - sc-48819 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

DNA pol β (N-19) - sc-5925 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-DNA Polymerase beta (di methyl R152) antibody - ab93672 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DNA Polymerase beta (di methyl R83) antibody - ab93673 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DNA Polymerase beta antibody - ab53059 from Abcam Prices $379.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DNA Polymerase beta antibody - ab92962 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DNA Polymerase beta antibody [61] - ab1831 from Abcam Prices $390.00 Sizes 250 µl Host Mouse Clonality Monoclonal Clone 61

Anti-DNA Polymerase beta antibody [EPR12722(B)] - ab175197 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR12722(B)

Anti-DNA Polymerase beta antibody [SPM177], prediluted - ab53923 from Abcam Prices $376.00 Sizes 7 ml Host Mouse Clonality Monoclonal Clone SPM177

Anti-DNA Polymerase beta antibody - C-terminal - ab133189 from Abcam Prices $378.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-POLB / DNA Polymerase Beta Antibody - LS-C22842 from LifeSpan Bioscience Prices $475.00 Sizes 500 µl Host Mouse Clonality Monoclonal

Anti-POLB / DNA Polymerase Beta Antibody - LS-C22843 from LifeSpan Bioscience Prices $385.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-POLB / DNA Polymerase Beta Antibody - LS-C22844 from LifeSpan Bioscience Prices $445.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POLB / DNA Polymerase Beta Antibody - LS-C64798 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-POLB / DNA Polymerase Beta Antibody - LS-C64799 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-POLB / DNA Polymerase Beta Antibody (clone 61, Azide-free) - LS-C87746 from LifeSpan Bioscience Prices $695.00, $1,085.00 Sizes 100 µg, 200 µg Host Mouse Clonality Monoclonal Clone 61

Anti-POLB / DNA Polymerase Beta Antibody (clone 61) - LS-C87745 from LifeSpan Bioscience Prices $295.00, $595.00, $1,015.00 Sizes 20 µg, 100 µg, 1 ml Host Mouse Clonality Monoclonal Clone 61

Anti-POLB / DNA Polymerase Beta Antibody (clone 18S, Biotin) - LS-C88355 from LifeSpan Bioscience Prices $325.00, $730.00, $1,165.00 Sizes 20 µg, 100 µg, 1 ml Host Mouse Clonality Monoclonal Clone 18S

Anti-POLB / DNA Polymerase Beta Antibody (clone 18S) - LS-C88354 from LifeSpan Bioscience Prices $280.00, $555.00, $920.00 Sizes 20 µg, 100 µg, 1 ml Host Mouse Clonality Monoclonal Clone 18S

Anti-POLB / DNA Polymerase Beta Antibody (clone 18S, Azide-free) - LS-C88356 from LifeSpan Bioscience Prices $610.00, $1,015.00 Sizes 100 µg, 200 µg Host Mouse Clonality Monoclonal Clone 18S

Anti-POLB / DNA Polymerase Beta Antibody (aa1-335) - LS-C121735 from LifeSpan Bioscience Prices $445.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-POLB / DNA Polymerase Beta Antibody (C-Terminus, clone 61) - LS-C95517 from LifeSpan Bioscience Prices $450.00, $750.00 Sizes 500 µl, 1 ml Host Mouse Clonality Monoclonal Clone 61

Anti-POLB / DNA Polymerase Beta Antibody - LS-C190729 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-POLB / DNA Polymerase Beta Antibody - LS-C309258 from LifeSpan Bioscience Prices $515.00 Sizes 50 µl Host Mouse Clonality Polyclonal

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