POLB

Gene Symbol POLB
Entrez Gene 5423
Alt Symbol -
Species Human
Gene Type protein-coding
Description polymerase (DNA directed), beta
Other Description DNA pol beta|DNA polymerase beta|DNA polymerase beta subunit|mutant DNA polymerase beta
Swissprots Q3KP48 P06746 B2RC78 Q6FI34
Accessions AAA60134 AAB37517 AAB37518 AAB60688 AAL91594 CAA48603 EAW63221 P06746 AK223537 BAD97257 AK294025 BAH11651 AK314976 BAG37475 BC100288 AAI00289 BC106909 AAI06910 BM678092 BP370570 CR536503 CAG38741 CR541802 CAG46601 D29013 BAA06099 JQ664683 AFI72772 JQ927442 L11607 AAB59441 M13140 AAA60133 S69873 AAD14051 XM_005273535 XP_005273592 XM_005273536 XP_005273593 XM_005273537 XP_005273594 XM_005273538 XP_005273595 XM_005273539 XP_005273596 XM_005273540 XP_005273597 XM_006716353 XP_006716416 XR_428311 NM_002690 NP_002681
Function Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. {ECO:0000269|PubMed:11805079, ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9572863}.
Subcellular Location Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
Top Pathways Base excision repair, HTLV-I infection, Viral carcinogenesis

Mouse/Human/Rat POLB / DNA Polymerase Beta ELISA Kit (Cell-Based ELISA) - LS-F1944 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 0.156-10 ng/ml

Human POLB / DNA Polymerase Beta ELISA Kit (Sandwich ELISA) - LS-F9956 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 0.051 ng/ml
Range 0.156-10 ng/ml

POLB (Human) IP-WB Antibody Pair - H00005423-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

polymerase (DNA directed) , beta, ELISA Kit - MBS9334842 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Polymerase beta Colorimetric Cell-Based ELISA Kit - CB5207 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

ELISA Kit for Polymerase DNA Directed Beta (POLb) - SEF721Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.051ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

DNA Polymerase beta ELISA Kit - DEIA-XYA554 from Creative Diagnostics

Category ELISA Kit

POLB ELISA Kit (Human) (OKCD01880) - OKCD01880 from Aviva Systems Biology

Category ELISA Kit
Prices $545.00
Sizes 96 wells
Sensitivity < 0.051 ng/mL
Range 0.156 - 10 ng/mL

anti-DNA polymerase beta antibody [18S] - ARG62468 from Arigo Biolaboratories

Category ELISA Kit

DNA polymerase beta, ELISA Kit - MBS285550 from MyBioSource

Category ELISA Kit
Prices $425.00, $720.00, $3,160.00, $6,055.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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