AKAP13

Gene Symbol AKAP13
Entrez Gene 11214
Alt Symbol AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47
Species Human
Gene Type protein-coding
Description A kinase (PRKA) anchor protein 13
Other Description A-kinase anchor protein 13|A-kinase anchoring protein|LBC oncogene|breast cancer nuclear receptor-binding auxiliary protein|guanine nucleotide exchange factor Lbc|human thyroid-anchoring protein 31|lymphoid blast crisis oncogene|non-oncogenic Rho GTPase-specific GTP exchange factor|protein kinase A-anchoring protein 13
Swissprots Q9Y5T6 Q96P79 Q9Y5T0 Q8WXQ6 Q59FP6 Q96JP6 Q86W90 Q14572 Q12802
Accessions EAX01973 EAX01974 EAX01975 EAX01976 Q12802 AB055890 BAB62913 AB209414 BAD92651 AF086293 AF126008 AAD21311 AF387101 AAL40923 AF406992 AAL11723 AK022014 AK026186 AK091210 AK125331 AK307618 AK309805 AK315885 BAF98776 AL133426 AL133427 AL133429 AL133430 AL135297 BC000269 BC009213 BC017368 BC019662 BC040109 BC050312 AAH50312 BC063592 BC089394 BC140862 AAI40863 BC171798 AAI71798 BC172356 AAI72356 CA306665 KC832804 M90360 AAA58670 NM_001270546 NP_001257475 NM_006738 NP_006729 NM_007200 NP_009131 NM_144767
Function Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. {ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Subcellular Location Cytoplasm. Nucleus. Membrane.
Tissue Specificity Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen- responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle. {ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.

AKAP 13 (A-1) - sc-393557 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AKAP 13 (A-1): sc-393557. Western blot analysis of AKAP 13 expression in non-transfected: sc-117752 (A) and human AKAP 13 transfected: sc-372397 (B) 293T whole cell lysates and human heart tissue extract (C).

AKAP 13 (A-3) - sc-393953 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AKAP 13 (A-3): sc-393953. Western blot analysis of AKAP 13 expression in non-transfected: sc-117752 (A) and human AKAP 13 transfected: sc-372397 (B) 293T whole cell lysates.

AKAP 13 (D-20) - sc-12431 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AKAP 13 (D-20): sc-12431. Western blot analysis of AKAP 13 expression in non-transfected: sc-117752 (A) and human AKAP 13 transfected: sc-372397 (B) 293T whole cell lysates.

AKAP 13 (H-284) - sc-368418 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

AKAP 13 (R-19) - sc-9336 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AKAP 13 (R-19): sc-9336. Western blot analysis of AKAP 13 expression in human heart tissue extract.

AKAP 13 (ZX-18) - sc-81902 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
AKAP 13 (ZX-18): sc-81902. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing nuclear and cytoplasmic localization.

Anti-AKAP13 antibody - ab74048 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AKAP13 antibody (ab74048) at 1/500 dilutionLane 1 : Extracts from Jurkat cellsLane 2 : Extracts from A549 cellsLane 3 : Extracts from Jurkat cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-AKAP13 antibody - ab56917 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Immunoperoxidase of monoclonal antibody to AKAP13 on formalin-fixed paraffin-embedded human spleen. [antibody concentration 1.5 ug/ml]

Anti-AKAP13 antibody - ab99377 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AKAP13 antibody (ab99377) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µg

Anti-AKAP13 antibody - ab56916 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-AKAP13 antibody (ab56916) at 5 µg/ml + 0.2 µg/lane of partial recombinant AKAP13 protein with a tagSecondaryGoat anti mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

Anti-AKAP13 antibody - ab99318 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of AKAP13 by Western Blot of Immunprecipitate. An antibody to AKAP13 at 0.1 µg/ml staining AKAP13 in HeLa whole cell lysate immunoprecipitated using ab99318 at 3 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 10 seconds.

Anti-LBC / AKAP13 Antibody (aa1850-1900) - LS-C288198 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LBC / AKAP13 Antibody (aa2754-2804) - LS-C288199 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LBC / AKAP13 Antibody - LS-C306169 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-LBC / AKAP13 Antibody (aa1-111) - LS-C306170 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-LBC / AKAP13 Antibody - LS-C309380 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LBC / AKAP13 Antibody (aa1-111) - LS-C309253 from LifeSpan Bioscience

Prices $620.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-LBC / AKAP13 Antibody - LS-C178487 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LBC / AKAP13 Antibody (aa721-770) - LS-C119002 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human heart tissue, using AKAP13 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-LBC / AKAP13 Antibody (Asp738) - LS-C177064 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of AKAP 13 (D738) pAb in paraffin-embedded human lung carcinoma tissue.

AKAP13 Antibody (3D6) - H00011214-M10 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D6
Western Blot: AKAP13 Antibody (3D6) [H00011214-M10] - Analysis of AKAP13 expression in HeLa.

AKAP13 Antibody (5B7) - H00011214-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5B7
Immunocytochemistry/Immunofluorescence: AKAP13 Antibody (5B7) [H00011214-M01] - Analysis of monoclonal antibody to AKAP13 on HeLa cell. Antibody concentration 10 ug/ml.

AKAP13 Antibody - NB100-68213 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

AKAP13 Antibody - NBP1-89163 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

AKAP13 Antibody - NBP1-00706 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: AKAP13 Antibody [NBP1-00706] - (WB) analysis of AKAP 13 (D738) antibody in extracts from Jurkat cells
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