| Gene Symbol |
AKAP13
|
| Entrez Gene |
11214
|
| Alt Symbol |
AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
A kinase (PRKA) anchor protein 13
|
| Other Description |
A-kinase anchor protein 13|A-kinase anchoring protein|LBC oncogene|breast cancer nuclear receptor-binding auxiliary protein|guanine nucleotide exchange factor Lbc|human thyroid-anchoring protein 31|lymphoid blast crisis oncogene|non-oncogenic Rho GTPase-specific GTP exchange factor|protein kinase A-anchoring protein 13
|
| Swissprots |
Q9Y5T6 Q96P79 Q9Y5T0 Q8WXQ6 Q59FP6 Q96JP6 Q86W90 Q14572 Q12802
|
| Accessions |
EAX01973 EAX01974 EAX01975 EAX01976 Q12802 AB055890 BAB62913 AB209414 BAD92651 AF086293 AF126008 AAD21311 AF387101 AAL40923 AF406992 AAL11723 AK022014 AK026186 AK091210 AK125331 AK307618 AK309805 AK315885 BAF98776 AL133426 AL133427 AL133429 AL133430 AL135297 BC000269 BC009213 BC017368 BC019662 BC040109 BC050312 AAH50312 BC063592 BC089394 BC140862 AAI40863 BC171798 AAI71798 BC172356 AAI72356 CA306665 KC832804 M90360 AAA58670 NM_001270546 NP_001257475 NM_006738 NP_006729 NM_007200 NP_009131 NM_144767
|
| Function |
Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. {ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Membrane.
|
| Tissue Specificity |
Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen- responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle. {ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
|